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作者:
Hurong Ge,Peipei Ma,Ding Yin,Qing Huang and Zhizhong Wang
文题:
Biocompatible and biodegradable β-cyclodextrin conjugate of butanoic acid: A potential formulation for colon health
期刊名:
Journal of Chemical and Pharmaceutical Research
期刊年份:
2013
卷(期),起止页码:
5(10):276-279
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wangzzsc: 金币+5, ★★★★★最佳答案, 十分感谢!有pdf版就更好了! 2014-05-20 22:02:44
oven1986: 检索EPI+1, 感谢应助! 2014-05-20 22:31:48
Accession number:       
20134817024482
        Title:        Biocompatible and biodegradable β-cyclodextrin conjugate of butanoic acid: A potential formulation for colon health
        Authors:         Ge, Hurong1; Ma, Peipei1; Yin, Ding1; Huang, Qing1; Wang, Zhizhong1
        Author affiliation:        1 Ningxia Medical University, Yinchuan, Ningxia, China
        Corresponding author:         Wang, Z.
        Source title:        Journal of Chemical and Pharmaceutical Research
        Abbreviated source title:        J. Chem. Pharm. Res.
        Volume:        5
        Issue:        10
        Issue date:        2013
        Publication year:        2013
        Pages:        276-279
        Language:        English
        E-ISSN:         09757384
        Document type:        Journal article (JA)
        Publisher:        Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India
        Abstract:        Butanoic acid is beneficial in the maintenance of colon health, and is the preferred energy substrate for the cells in the colon. Here, butanoic acid was covalently attached to β-cyclodextrin through ester linkage using sodium hydride as the deproton reagent, and the preliminary release behavior of butanoic acid in the colonic contents of rats was investigated at 37 °C. Butanoic acid was almost released 57.3% from the β-cyclodextrin conjugate after 12 h in the colonic contents of rats, via the biodegradation by glycosidases and hydrolases in the colon. This fact demonstrates that β-cyclodextrin could act as a carrier for an orally administered colon-targeting delivery of butanoic acid as a nutrient.
        Number of references:        18
        Main heading:         Cyclodextrins
        Controlled terms:         Biocompatibility  -  Biodegradation  -  Butyric acid  -  Nutrition  -  Rats  -  Sodium compounds
        Uncontrolled terms:         Colon-targeting delivery  -  Colonic content  -  Ester linkages  -  Glycosidases  -  Potential formulations  -  Release behaviors  -  Sodium hydrides
        Classification code:         461.7 Health Care -  461.9 Biology -  462.5 Biomaterials (including synthetics) -  801.2 Biochemistry -  804.1 Organic Compounds
        Database:        Compendex
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3楼: Originally posted by 流光逸影 at 2014-05-20 22:22:04
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