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作者: Hurong Ge,Peipei Ma,Ding Yin,Qing Huang and Zhizhong Wang 文题: Biocompatible and biodegradable β-cyclodextrin conjugate of butanoic acid: A potential formulation for colon health 期刊名: Journal of Chemical and Pharmaceutical Research 期刊年份: 2013 卷(期),起止页码: 5(10):276-279 |
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wangzzsc: 金币+5, ★★★★★最佳答案, 十分感谢！有pdf版就更好了！ 2014-05-20 22:02:44
oven1986: 检索EPI+1, 感谢应助！ 2014-05-20 22:31:48
感谢参与，应助指数 +1
wangzzsc: 金币+5, ★★★★★最佳答案, 十分感谢！有pdf版就更好了！ 2014-05-20 22:02:44
oven1986: 检索EPI+1, 感谢应助！ 2014-05-20 22:31:48
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Accession number: 20134817024482 Title: Biocompatible and biodegradable β-cyclodextrin conjugate of butanoic acid: A potential formulation for colon health Authors: Ge, Hurong1; Ma, Peipei1; Yin, Ding1; Huang, Qing1; Wang, Zhizhong1 Author affiliation: 1 Ningxia Medical University, Yinchuan, Ningxia, China Corresponding author: Wang, Z. Source title: Journal of Chemical and Pharmaceutical Research Abbreviated source title: J. Chem. Pharm. Res. Volume: 5 Issue: 10 Issue date: 2013 Publication year: 2013 Pages: 276-279 Language: English E-ISSN: 09757384 Document type: Journal article (JA) Publisher: Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India Abstract: Butanoic acid is beneficial in the maintenance of colon health, and is the preferred energy substrate for the cells in the colon. Here, butanoic acid was covalently attached to β-cyclodextrin through ester linkage using sodium hydride as the deproton reagent, and the preliminary release behavior of butanoic acid in the colonic contents of rats was investigated at 37 °C. Butanoic acid was almost released 57.3% from the β-cyclodextrin conjugate after 12 h in the colonic contents of rats, via the biodegradation by glycosidases and hydrolases in the colon. This fact demonstrates that β-cyclodextrin could act as a carrier for an orally administered colon-targeting delivery of butanoic acid as a nutrient. Number of references: 18 Main heading: Cyclodextrins Controlled terms: Biocompatibility - Biodegradation - Butyric acid - Nutrition - Rats - Sodium compounds Uncontrolled terms: Colon-targeting delivery - Colonic content - Ester linkages - Glycosidases - Potential formulations - Release behaviors - Sodium hydrides Classification code: 461.7 Health Care - 461.9 Biology - 462.5 Biomaterials (including synthetics) - 801.2 Biochemistry - 804.1 Organic Compounds Database: Compendex |
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