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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
wangtian3778: 金币+8, ★★★★★最佳答案 2014-05-04 09:38:28
oven1986: 检索EPI+1, 感谢应助！ 2014-05-04 20:04:53
Monograph Number: 0001984
Title: Cephapirin Sodium
CAS Registry Number: 24356-60-3
CAS Name: (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
Additional Names: 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid acetate monosodium salt; 7-[a-(4-pyridylthio)acetamido]cephalosporanic acid sodium salt; sodium 7-(pyrid-4-ylthioacetamido)cephalosporanate
Manufacturers' Codes: BL-P-1322
Trademarks: Ambrocef (Lusofarmaco); Brisfirina (BMS); Bristocef (BMS); Cefadyl (BMS); Cefa-Lak (Fort Dodge); Piricef (CT); ToDay (Franklin)
Molecular Formula: C17H16N3NaO6S2
Molecular Weight: 445.45
Percent Composition: C 45.84%, H 3.62%, N 9.43%, Na 5.16%, O 21.55%, S 14.40%
Literature References: A cephalosporin C antibiotic effective against gram-pos. and gram-neg. bacteria including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. Prepn: L. B. Crast, ZA 6707783; eidem, US 3422100 (1968, 1970 both to Bristol-Myers). Alternate processes: H. H. Silvestri, D. A. Johnson, US 3503967; R. E. Havranek, L. B. Crast, US 3578661 (1970, 1971 both to Bristol-Myers); L. B. Crast et al., J. Med. Chem. 16, 1413 (1973). Activity studies: Chisholm et al., Antimicrob. Agents Chemother. 1969, 244; Axelrod et al., Appl. Microbiol. 22, 904 (1971); Bran et al., Antimicrob. Agents Chemother. 1, 35 (1972); Wiesner et al., ibid. 303.
Properties: White crystalline powder, sol in water.
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins. |
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