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wangtian3778

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[求助] 求助头孢匹林钠的默克索引

求助头孢匹林钠的默克索引,英文名为cefapirin sodium,CAS号为24356-60-3,谢谢
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【答案】应助回帖

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感谢参与,应助指数 +1
wangtian3778: 金币+8, ★★★★★最佳答案 2014-05-04 09:38:28
oven1986: 检索EPI+1, 感谢应助! 2014-05-04 20:04:53
Monograph Number:  0001984
Title:  Cephapirin Sodium
CAS Registry Number:  24356-60-3
CAS Name:  (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
Additional Names:  3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid acetate monosodium salt;  7-[a-(4-pyridylthio)acetamido]cephalosporanic acid sodium salt;  sodium 7-(pyrid-4-ylthioacetamido)cephalosporanate
Manufacturers' Codes:  BL-P-1322
Trademarks:  Ambrocef (Lusofarmaco);  Brisfirina (BMS);  Bristocef (BMS);  Cefadyl (BMS);  Cefa-Lak (Fort Dodge);  Piricef (CT);  ToDay (Franklin)
Molecular Formula:  C17H16N3NaO6S2
Molecular Weight:  445.45
Percent Composition:  C 45.84%, H 3.62%, N 9.43%, Na 5.16%, O 21.55%, S 14.40%
Literature References:  A cephalosporin C antibiotic effective against gram-pos. and gram-neg. bacteria including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis.  Prepn:  L. B. Crast, ZA 6707783; eidem, US 3422100 (1968, 1970 both to Bristol-Myers). Alternate processes:  H. H. Silvestri, D. A. Johnson, US 3503967; R. E. Havranek, L. B. Crast, US 3578661 (1970, 1971 both to Bristol-Myers); L. B. Crast et al., J. Med. Chem. 16, 1413 (1973).  Activity studies:  Chisholm et al., Antimicrob. Agents Chemother. 1969, 244; Axelrod et al., Appl. Microbiol. 22, 904 (1971); Bran et al., Antimicrob. Agents Chemother. 1, 35 (1972); Wiesner et al., ibid. 303.
Properties:  White crystalline powder, sol in water.
Therap-Cat:  Antibacterial.
Therap-Cat-Vet:  Antibacterial.
Keywords:  Antibacterial (Antibiotics); ?Lactams; Cephalosporins.
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