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victorapm木虫 (正式写手)
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[求助]
求助文献的SCI检索号是多少，最好能给ISI上全部的信息，谢！
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题目：Synthesis and bioactivity of new Finasteride conjugate. 作者：Shuang, Zhao Jiazhen, Wu Lijuan, Yang Zhuo, Li Dahai, Yu Jinfeng, Li Jing, Yu Yongtao, Liang En-Si, Wang Xuexun, Fang 发表日期：2011 ，期卷，页码：21(11):3439-42. 链接：http://www.sciencedirect.com/sci ... i/S0960894X11004318 |
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阿努
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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
victorapm: 金币+5, ★有帮助 2014-03-18 12:14:37
jssxh: 金币+3, 检索EPI+1, 谢谢参与，请继续关注本版块！ 2014-03-18 15:03:42
感谢参与，应助指数 +1
victorapm: 金币+5, ★有帮助 2014-03-18 12:14:37
jssxh: 金币+3, 检索EPI+1, 谢谢参与，请继续关注本版块！ 2014-03-18 15:03:42
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标题: Synthesis and bioactivity of new Finasteride conjugate 作者: Zhao, S (Zhao Shuang); Wu, JZ (Wu Jiazhen); Yang, LJ (Yang Lijuan); Li, Z (Li Zhuo); Yu, DH (Yu Dahai); Li, JF (Li Jinfeng); Yu, J (Yu Jing); Liang, YT (Liang Yongtao); Wang, ES (Wang En-si); Fang, XX (Fang Xuexun) 来源出版物: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 卷: 21 期: 11 页: 3439-3442 DOI: 10.1016/j.bmcl.2011.03.102 出版年: JUN 1 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 30 摘要: Finasteride is a synthetic 4-azasteroid compound that acts by inhibiting type II 5 alpha-reductase, the enzyme that converts the androgen testosterone to 5 alpha-dihydrotestosterone. It was approved by the US FDA for the treatment of benign prostatic hyperplasia and male pattern baldness. Here the acylation product of Finasteride C-18 amide N-polimod was synthesized by employing acylation reaction with polimod amide as a pivotal intermediate. The structure of the key intermediate and target molecule was confirmed by infrared spectrum, (1)H NMR and (13)C NMR spectra and mass spectrum, and the inhibition of the steroid 5 alpha-reductase and the rats' benign prostatic hyperplasia by the new Finasteride conjugate and Finasteride was also determined. The inhibition of the Finasteride conjugate on 5 alpha-reductase was stronger than that of Finasteride. Prostate hyperplasia of rats was reduced by Finasteride conjugate treatment similar to the Finasteride treatment. However, the Finasteride conjugate treated animals showed better viable condition than the Finasteride treated ones, suggesting the new compound may have improved toxicity profile than Finasteride. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000290708300053 语种: English 文献类型: Article 作者关键词: Synthesis; Finasteride; Conjugates; 5 alpha-Reductase; Polimod KeyWords Plus: BENIGN PROSTATIC HYPERPLASIA; STEROID 5-ALPHA-REDUCTASE; INHIBITORS; MEN 地址: [Zhao Shuang; Li Zhuo; Liang Yongtao; Wang En-si] Jilin Univ, Coll Life Sci, Changchun 130021, Peoples R China. [Wu Jiazhen; Yu Dahai; Fang Xuexun] Jilin Univ, Key Lab Mol Enzymol & Enzyme Engn, Minist Educ, Changchun 130012, Peoples R China. [Yang Lijuan; Yu Jing; Wang En-si] Jilin Univ, Coll Pharm, Changchun 130021, Peoples R China. [Wu Jiazhen] Chinese Acad Sci, State Key Lab Electroanalyt Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China. [Li Jinfeng] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China. 通讯作者地址: Wang, ES (通讯作者),Jilin Univ, Coll Life Sci, Changchun 130021, Peoples R China. 电子邮件地址: dahaiyu.lipase@yahoo.com.cn 出版商: PERGAMON-ELSEVIER SCIENCE LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND Web of Science 类别: Chemistry, Medicinal; Chemistry, Organic 研究方向: Pharmacology & Pharmacy; Chemistry IDS 号: 765LR ISSN: 0960-894X 29 字符的来源出版物名称缩写: BIOORG MED CHEM LETT ISO 来源出版物缩写: Bioorg. Med. Chem. Lett. 来源出版物页码计数: 4 |
2楼2014-03-18 11:13:06
