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Ͷ¸åInternational Journal of Cancer±»¾ÜÁË£¬ÀϰåÒªÎÒargue£¬´ó¼Ò¿´¿´¿ÉÄÜÂ𣿠ÒÑÓÐ3È˲ÎÓë
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ÎÄÕ±»¾ÜÁË£¬µ«ÊÇ¿´ÁËÏÂÆÀÂÛ£¬ÀϰåÒªÎÒargue£¬´ó¼Ò˵ÎÒÊǰ´ÕÕÒâ¼ûÐÞ¸ÄÁËÔÙargue»¹ÊÇÏÈargueÒªÇóÐ޸ģ¬ÔÙ²¹Êý¾Ý£¬argueÏ£Íû´óÂ𣿠ÒÔÏÂÊÇÉó¸åÒâ¼û£º 05-Mar-2014 Re: IJC-14-0243 Dear XXX: Thank you for submitting your manuscript XXX to the International Journal of Cancer. Our reviewing process has now been completed, and your paper has been reviewed by three outside referees and studied by the Editors. After careful consideration, we regret to say that we find your manuscript unsuited for publication in the IJC. Our decision is based on the lower priority of the work in light of current competition for publication and our stringent criteria. You can view the reviewer comments below. We do hope that you find the reviews helpful and remain sorry that our answer cannot be a positive one. Thank you for your interest in IJC. We hope that this decision will not dissuade you from submitting your work again in the future. Yours sincerely, Prof. Peter Lichter Editor-in-Chief International Journal of Cancer Reviewer: 1 Comments to Author The manuscript by XXX shows that XXXXX£¨ÎÒµÄÎÄÕÂÄÚÈݸÅÀ¨£©and therefore we see significant bystander effect. The data are robust and clear. Major criticisms: In my opinion, this study lacks novelty,given that a recently published paper by the same group addressed similar questions except liposomes part. £¨µ«ÊÇÎÒÁ½ÆªÎÄÕ¿´Ï´´ÐµãÍêÈ«²»Ò»Ñù°¡£¬ÕâÆªÊÇÉÏÆªµÄÉîÈ뻯£¬Ð§¹û¼ÓÇ¿ÁË£¬¶øÇÒÑо¿ÁË»úÖÆ,ÍêÈ«²»Ò»Ñù°¡£¬Ö®Ç°ÊÇÒ»¸öÔØÌå°ÐÏòÏÖÔÚÊÇË«°ÐÏò°¡£©¡£ Reviewer: 2 Comments to Author The manuscript entitled XXX demonstrates XXX£¨ÎÒµÄÎÄÕÂÄÚÈÝ)¡£ The authors showed XXX£¨ÎÄÕµĴ´ÐµãºÍ½áÂÛ£¬µÚ¶þ¸öÆÀί¶¼¿´¶®ÕâÆªµÄ´´ÐÂÒâÒåÁË£©¡£ Although there are a few points that need to be clarified, the manuscript is well written: 1. Page 5, line 31:XXX£¨ËµÎÒÒ»¸ö¸ÅÄî²»¹»È«£©. Please consider adding the following citation to the text (one example of many): XXX(ÐèÒªÌí¼ÓµÄÎÄÏ×£©¡£ 2. Page 5, line 41: XXX £¨Ò²ÊÇÒ»¸ö¸ÅÄîÐèÒª²¹³ä£©. Relevant reference can be: XXX(ÐèÒªÌí¼ÓµÄÎÄÏ×£© 3. Page 7, line 51-57:XXX (ÎÒµÄÒ»¸ö½á¹û£©. Can the authors clarify the reason for not choosing the same administration route for XXX£¨Ò»¸öÐèÒª½âÊÍΪʲôʵÑéÕâô×öµÄµØ·½£©? 4. Efficacy study: Did the authors perform an in vivo survival study XXX(ÒªÇó²¹³äÒ»¸öÌåÄÚʵÑ飩 5. Page 18, line 54: "XXX¡°£¨ÎÒµÄÒ»¸ö½áÂÛ£©. Please mention the reason for it: large-sized particles. £¨¾ÍÊÇÎÄ×ָĶ¯Ï£© 6. Did the authors perform long-term storage stability analysis for the liposomal formulation £¨¾ÍÊDz¹³äÒ»¸öÎȶ¨ÐÔʵÑ飬Æäʵ×öÁËÖ»ÊÇû·ÅÉÏÈ¥£¬²»³ÉÎÊÌ⣩? Reviewer: 3 Comments to Author The authors looked at the therapeutic efficacy of XXXX£¨ÎÄÕÂÄÚÈÝ£©. The study demonstrates significant XXX (ʵÑé½á¹û£©, and showed potential for safe and efficient gene therapy £¨´´ÐµãºÍÁÙ´²Ó¦Óã©. Following concerns need to be addressed: 1. Figure 2D versus 2E: The authors used XXX £¨ÈÃÎÒ²¹³äÒ»¸ö¶Ô¶¾ÐÔÊý¾ÝµÄ½âÊÍ˵Ã÷£© 2. Figure 4E: The high apoptosis with XXX £¨ÎÒµÄÒ©Î would be better reflected by quantitative data. Please provide the comparative data with ratio of apoptotic cells in a given region with each formulation. 3. Figure 4F: The goal of XXX £¨ÎÒµÄÑо¿Ä¿µÄ£©. The integrity of the normal lung tissue would be best understood if a histologic score with each formulation is provided. 4. Many errors occur throughout the manuscript which need revision. £¨¿´À´Òâ˼ÊÇÐèÒªÓïÑÔÉϵĸĽø£¬»¹ÊÇÓÐÓï·¨´íÎó£© Thanks. [ ·¢×ÔÊÖ»ú°æ http://muchong.com/3g ] [ Last edited by titankop on 2014-3-7 at 14:56 ] |
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