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Anticancer Activity of Novel Platinum Complex as DNA Binders
Authors: Xu Jian Luo, Qi Pin Qin, Yu Lan Li, Yan Cheng Liu
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Accession number:  20134416916282

  Title:  Anticancer activity of novel platinum complex as DNA binders
  Authors:  Luo, Xu Jian1, 3 Email author 823998478@qq.com; Qin, Qi Pin2 Email author qinqipin2007@126.com; Li, Yu Lan2 Email author lyl3842@163.com; Liu, Yan Cheng2 Email author 26043076@qq.com  
  Author affiliation:  1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China  
   2 State Key Laboratory Cultivation Base for the Chemistry and, Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, China  
   3 School of Chemistry and Material, Yulin Normal University, Yulin 537000, China  
  Corresponding author:  Luo, X. J. (823998478@qq.com)  
  Source title:  Advanced Materials Research
  Abbreviated source title:  Adv. Mater. Res.
  Volume:  781-784
  Monograph title:  Advances in Chemical Engineering III
  Issue date:  2013
  Publication year:  2013
  Pages:  1107-1110
  Language:  English
  ISSN:  10226680  
  ISBN-13:  9783037858134  
  Document type:  Conference article (CA)
  Conference name:  3rd International Conference on Chemical Engineering and Advanced Materials, CEAM 2013
  Conference date:  July 6, 2013 - July 7, 2013
  Conference location:  Guangzhou, China
  Conference code:  100403  
  Publisher:  Trans Tech Publications Ltd, Kreuzstrasse 10, Zurich-Durnten, CH-8635, Switzerland
  Abstract:  A new phenanthroimidazole platinum(II) complex has been synthesized and characterized by IR, NMR, ESI-MS, element analysis. The affinities of the complex toward ct-DNA was determined by circular dichroism absorption (CD), UV-Vis absorption. Results indicate that the complex interact with ct-DNA by classical intercalating mode. The cytotoxicities of the complex was screened against four cancer cell lines and normal cells of HL-7702 in comparison to cisplatin and it showed a higher activity than cisplatin, with IC50 values in the range 8.74-17.11 ¦Ìmol/L. Furthermore, the complex displayed lower cytotoxic activities to HL-7702 (normal cell) compared with the cancer cell lines. © (2013) Trans Tech Publications, Switzerland.
  Number of references:  9
  Main heading:  DNA  
  Controlled terms:  Cell culture  -  Cells  -  Chemical engineering  -  Cytotoxicity  -  Platinum  -  Platinum compounds  
  Uncontrolled terms:  Anticancer activities  -  Cancer cell lines  -  Circular dichroism absorption  -  Cytotoxic activities  -  Interaction  -  Phenanthroimidazole  -  Platinum complexes  -  UV-vis absorptions  
  Classification code:  461 Bioengineering and Biology -  547.1 Precious Metals -  804.1 Organic Compounds -  805.1 Chemical Engineering -  805.1.1 Biochemical Engineering
  DOI:  10.4028/www.scientific.net/AMR.781-784.1107
  Database:  Compendex
   Compilation and indexing terms, © 2013 Elsevier Inc.

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