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麻烦虫子们帮忙查文章是否被EI收录 Anticancer Activity of Novel Platinum Complex as DNA Binders Authors: Xu Jian Luo, Qi Pin Qin, Yu Lan Li, Yan Cheng Liu |
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baiyuefei
版主 (文学泰斗)
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Accession number: 20134416916282 Title: Anticancer activity of novel platinum complex as DNA binders Authors: Luo, Xu Jian1, 3 Email author 823998478@qq.com; Qin, Qi Pin2 Email author qinqipin2007@126.com; Li, Yu Lan2 Email author lyl3842@163.com; Liu, Yan Cheng2 Email author 26043076@qq.com Author affiliation: 1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China 2 State Key Laboratory Cultivation Base for the Chemistry and, Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, China 3 School of Chemistry and Material, Yulin Normal University, Yulin 537000, China Corresponding author: Luo, X. J. (823998478@qq.com) Source title: Advanced Materials Research Abbreviated source title: Adv. Mater. Res. Volume: 781-784 Monograph title: Advances in Chemical Engineering III Issue date: 2013 Publication year: 2013 Pages: 1107-1110 Language: English ISSN: 10226680 ISBN-13: 9783037858134 Document type: Conference article (CA) Conference name: 3rd International Conference on Chemical Engineering and Advanced Materials, CEAM 2013 Conference date: July 6, 2013 - July 7, 2013 Conference location: Guangzhou, China Conference code: 100403 Publisher: Trans Tech Publications Ltd, Kreuzstrasse 10, Zurich-Durnten, CH-8635, Switzerland Abstract: A new phenanthroimidazole platinum(II) complex has been synthesized and characterized by IR, NMR, ESI-MS, element analysis. The affinities of the complex toward ct-DNA was determined by circular dichroism absorption (CD), UV-Vis absorption. Results indicate that the complex interact with ct-DNA by classical intercalating mode. The cytotoxicities of the complex was screened against four cancer cell lines and normal cells of HL-7702 in comparison to cisplatin and it showed a higher activity than cisplatin, with IC50 values in the range 8.74-17.11 μmol/L. Furthermore, the complex displayed lower cytotoxic activities to HL-7702 (normal cell) compared with the cancer cell lines. © (2013) Trans Tech Publications, Switzerland. Number of references: 9 Main heading: DNA Controlled terms: Cell culture - Cells - Chemical engineering - Cytotoxicity - Platinum - Platinum compounds Uncontrolled terms: Anticancer activities - Cancer cell lines - Circular dichroism absorption - Cytotoxic activities - Interaction - Phenanthroimidazole - Platinum complexes - UV-vis absorptions Classification code: 461 Bioengineering and Biology - 547.1 Precious Metals - 804.1 Organic Compounds - 805.1 Chemical Engineering - 805.1.1 Biochemical Engineering DOI: 10.4028/www.scientific.net/AMR.781-784.1107 Database: Compendex Compilation and indexing terms, © 2013 Elsevier Inc. Full-text and Local Holdings Links |
2楼2013-12-20 22:45:03
baiyuefei
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- LS-EPI: 1647
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- 在线: 13276.5小时
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- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
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3楼2013-12-20 22:45:13