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¹§Ï²±»ÊÕ¼ÁË Accession number: 20132816486065 Title: Studies on the material properties of platinum complex binding to human telomeric G-quadruplex DNA Authors: Luo, Xu Jian1, 2, 3 Email author 823998478@qq.com; Qin, Qi Pin2 Email author qinqipin2007@126.com; Li, Yu Lan2 Email author lyl3842@163.com; Liu, Yan Cheng2 Email author 26043076@qq.com Author affiliation: 1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China 2 State Key Lab. Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, China 3 School of Chemistry and Material, Yulin Normal University, Yulin 537000, China Corresponding author: Luo, X. J. (823998478@qq.com) Source title: Advanced Materials Research Abbreviated source title: Adv. Mater. Res. Volume: 700 Monograph title: Advanced Research on Advanced Structure, Materials and Engineering II Issue date: 2013 Publication year: 2013 Pages: 63-66 Language: English ISSN: 10226680 ISBN-13: 9783037857038 Document type: Conference article (CA) Conference name: 2013 2nd International Conference on Advanced Structure, Materials and Engineering, ASME 2013 Conference date: April 13, 2013 - April 14, 2013 Conference location: Guangzhou, China Conference code: 97632 Sponsor: International Science and Education Researcher Association, China; Beijing Gireida Education Research Center; VIP-Information Conference Center, China Publisher: Trans Tech Publications Ltd, Kreuzstrasse 10, Zurich-Durnten, CH-8635, Switzerland Abstract: A new material of cation platinum(II) complex has been synthesized and characterized. The new material binding properties with human telomeric G-quadruplex DNA (G4-Htel DNA) and ct-DNA were examined by UV-Vis and CD spectroscopic methods. The results showed that complex exhibited higher binding affinity and binding intensity to G4-Htel DNA (up to Kb = 1.54¡Á106 M-1) and with selectivity (up to 11-fold) over duplex DNA. The CD results suggests the antiparallel structure of G-quadruplex can remain stable in the presence of platinum complex and the complex may bind to DNA by intercalation mode. © (2013) Trans Tech Publications, Switzerland. Number of references: 8 Main heading: DNA Controlled terms: Binding energy - Materials properties - Platinum - Spectroscopic analysis Uncontrolled terms: Binding affinities - Binding intensity - Binding properties - Duplex DNA - G-quadruplexes - Interaction - Platinum complexes - Spectroscopic method Classification code: 421 Strength of Building Materials; Mechanical Properties - 423 Non Mechanical Properties and Tests of Building Materials - 547.1 Precious Metals - 801 Chemistry DOI: 10.4028/www.scientific.net/AMR.700.63 Database: Compendex |
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