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Studies on the Material Properties of Platinum Complex Binding to Human Telomeric G-Quadruplex DNA

Authors: Xu Jian Luo, Qi Pin Qin, Yu Lan Li, Yan Cheng Liu
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Accession number:  20132816486065

  Title:  Studies on the material properties of platinum complex binding to human telomeric G-quadruplex DNA
  Authors:  Luo, Xu Jian1, 2, 3 Email author 823998478@qq.com; Qin, Qi Pin2 Email author qinqipin2007@126.com; Li, Yu Lan2 Email author lyl3842@163.com; Liu, Yan Cheng2 Email author 26043076@qq.com  
  Author affiliation:  1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China  
   2 State Key Lab. Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, China  
   3 School of Chemistry and Material, Yulin Normal University, Yulin 537000, China  
  Corresponding author:  Luo, X. J. (823998478@qq.com)  
  Source title:  Advanced Materials Research
  Abbreviated source title:  Adv. Mater. Res.
  Volume:  700
  Monograph title:  Advanced Research on Advanced Structure, Materials and Engineering II
  Issue date:  2013
  Publication year:  2013
  Pages:  63-66
  Language:  English
  ISSN:  10226680  
  ISBN-13:  9783037857038  
  Document type:  Conference article (CA)
  Conference name:  2013 2nd International Conference on Advanced Structure, Materials and Engineering, ASME 2013
  Conference date:  April 13, 2013 - April 14, 2013
  Conference location:  Guangzhou, China
  Conference code:  97632  
  Sponsor:  International Science and Education Researcher Association, China; Beijing Gireida Education Research Center; VIP-Information Conference Center, China
  Publisher:  Trans Tech Publications Ltd, Kreuzstrasse 10, Zurich-Durnten, CH-8635, Switzerland
  Abstract:  A new material of cation platinum(II) complex has been synthesized and characterized. The new material binding properties with human telomeric G-quadruplex DNA (G4-Htel DNA) and ct-DNA were examined by UV-Vis and CD spectroscopic methods. The results showed that complex exhibited higher binding affinity and binding intensity to G4-Htel DNA (up to Kb = 1.54¡Á106 M-1) and with selectivity (up to 11-fold) over duplex DNA. The CD results suggests the antiparallel structure of G-quadruplex can remain stable in the presence of platinum complex and the complex may bind to DNA by intercalation mode. © (2013) Trans Tech Publications, Switzerland.
  Number of references:  8
  Main heading:  DNA  
  Controlled terms:  Binding energy  -  Materials properties  -  Platinum  -  Spectroscopic analysis  
  Uncontrolled terms:  Binding affinities  -  Binding intensity  -  Binding properties  -  Duplex DNA  -  G-quadruplexes  -  Interaction  -  Platinum complexes  -  Spectroscopic method  
  Classification code:  421 Strength of Building Materials; Mechanical Properties -  423 Non Mechanical Properties and Tests of Building Materials -  547.1 Precious Metals -  801 Chemistry
  DOI:  10.4028/www.scientific.net/AMR.700.63
  Database:  Compendex
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