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【答案】应助回帖
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jssxh: 检索EPI+1, 谢谢参与，请继续关注本版块！ 2013-12-23 08:18:11
llxxjj(江南的竹代发): 金币+5 2014-03-06 20:38:39
恭喜被收录了
Accession number: 20132816486065
Title: Studies on the material properties of platinum complex binding to human telomeric G-quadruplex DNA
Authors: Luo, Xu Jian1, 2, 3 Email author 823998478@qq.com; Qin, Qi Pin2 Email author qinqipin2007@126.com; Li, Yu Lan2 Email author lyl3842@163.com; Liu, Yan Cheng2 Email author 26043076@qq.com
Author affiliation: 1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, China
2 State Key Lab. Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, China
3 School of Chemistry and Material, Yulin Normal University, Yulin 537000, China
Corresponding author: Luo, X. J. (823998478@qq.com)
Source title: Advanced Materials Research
Abbreviated source title: Adv. Mater. Res.
Volume: 700
Monograph title: Advanced Research on Advanced Structure, Materials and Engineering II
Issue date: 2013
Publication year: 2013
Pages: 63-66
Language: English
ISSN: 10226680
ISBN-13: 9783037857038
Document type: Conference article (CA)
Conference name: 2013 2nd International Conference on Advanced Structure, Materials and Engineering, ASME 2013
Conference date: April 13, 2013 - April 14, 2013
Conference location: Guangzhou, China
Conference code: 97632
Sponsor: International Science and Education Researcher Association, China; Beijing Gireida Education Research Center; VIP-Information Conference Center, China
Publisher: Trans Tech Publications Ltd, Kreuzstrasse 10, Zurich-Durnten, CH-8635, Switzerland
Abstract: A new material of cation platinum(II) complex has been synthesized and characterized. The new material binding properties with human telomeric G-quadruplex DNA (G4-Htel DNA) and ct-DNA were examined by UV-Vis and CD spectroscopic methods. The results showed that complex exhibited higher binding affinity and binding intensity to G4-Htel DNA (up to Kb = 1.54×106 M-1) and with selectivity (up to 11-fold) over duplex DNA. The CD results suggests the antiparallel structure of G-quadruplex can remain stable in the presence of platinum complex and the complex may bind to DNA by intercalation mode. © (2013) Trans Tech Publications, Switzerland.
Number of references: 8
Main heading: DNA
Controlled terms: Binding energy - Materials properties - Platinum - Spectroscopic analysis
Uncontrolled terms: Binding affinities - Binding intensity - Binding properties - Duplex DNA - G-quadruplexes - Interaction - Platinum complexes - Spectroscopic method
Classification code: 421 Strength of Building Materials; Mechanical Properties - 423 Non Mechanical Properties and Tests of Building Materials - 547.1 Precious Metals - 801 Chemistry
DOI: 10.4028/www.scientific.net/AMR.700.63
Database: Compendex |
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