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小木虫论坛-学术科研互动平台 » 材料区 » 生物材料 » 纳米生物材料 » 光敏剂波长匹配求助
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vwangvhaov

木虫 (小有名气)

[求助] 光敏剂波长匹配求助

二氢卟吩e6这种光敏剂在400nm与660nm有吸收峰，目前文献中都是应用660nm进行光动力产生单线态氧。用400nm的从没有见过。大虾们能否告诉我400nm如果有波长匹配的话，是否能在400nm出激发产生单线态氧呢？？？
感谢！
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赶紧毕业
1楼 2013-12-09 16:36:20
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pepperp

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【答案】应助回帖

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vwangvhaov: 金币+10, ★★★很有帮助 2013-12-09 16:53:44
markar: 金币+1, 感谢回帖交流！ 2013-12-09 22:12:04
应该可以，但400属紫外光，一般应用长波长的光才好
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2楼2013-12-09 16:50:10
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vwangvhaov

木虫 (小有名气)
引用回帖:
2楼: Originally posted by pepperp at 2013-12-09 16:50:10
应该可以，但400属紫外光，一般应用长波长的光才好

您那有关于光照与光敏剂作用的详细机理么？我想确定下400nm是否能够起作用。再有就是用长波长的目的是什么呢？只是要求穿透性强么？
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赶紧毕业
3楼2013-12-09 16:53:27
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pepperp

至尊木虫 (文坛精英)
引用回帖:
3楼: Originally posted by vwangvhaov at 2013-12-09 16:53:27
您那有关于光照与光敏剂作用的详细机理么？我想确定下400nm是否能够起作用。再有就是用长波长的目的是什么呢？只是要求穿透性强么？...

没有。
安全和姣好的穿透能力
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4楼2013-12-09 16:56:42
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aircraftvip

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【答案】应助回帖

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感谢参与，应助指数 +1
markar: 金币+1, 感谢回帖交流！ 2013-12-09 22:12:18
vwangvhaov: 金币+10, ★★★★★最佳答案 2013-12-10 07:36:57
''Tissue is much more transparent at longer wavelengths (~700–850 nm). Absorbing at longer wavelengths would allow the light to penetrate deeper, and allow the treatment of larger tumors.''- wikipedia

J Biomed Opt. 2012 Aug;17(8):088001-1. doi: 10.1117/1.JBO.17.8.088001.
Comparison of photodynamic therapy with different excitation wavelengths using a dynamic model of aminolevulinic acid-photodynamic therapy of human skin.
Liu B, Farrell TJ, Patterson MS.
Source
McMaster University, Department of Medical Physics and Applied Radiation Sciences, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4K1.
Abstract
Different wavelength light sources are used in photodynamic therapy (PDT) of the skin to treat different conditions. Clinical studies show inconsistent results for the effectiveness of aminolevulinic acid (ALA)-PDT performed at different wavelengths. In order to understand the effect of treatment wavelength, a theoretical study was performed to calculate time-resolved depth-dependent distributions of PDT components including ground-state oxygen, sensitizer, and reacted singlet oxygen for different treatment wavelengths (405, 523, and 633 nm) using a numerical model of ALA-PDT of human skin. This model incorporates clinically relevant features of the PDT process including light attenuation, photobleaching, oxygen consumption, and diffusion, as well as tissue perfusion. The calculations show that the distributions of these quantities are almost independent of the treatment wavelength to a depth of about 1 mm. In this surface region, PDT-induced hypoxia is the dominant process. At greater depths, the production of singlet -oxygen is governed by the penetration of the treatment light. Two noninvasive PDT dosimetry approaches: the cumulative singlet oxygen luminescence (CSOL) and the fractional fluorescence bleaching metric, were investigated and compared for all three wavelengths. Although CSOL was more robust, both metrics provided correlations with the singlet oxygen dose in the upper dermis that were almost independent of treatment wavelength. This relationship breaks down at greater depths because light penetration depends on wavelength.
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格物致知，知行合一
5楼2013-12-09 17:55:37
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vwangvhaov

木虫 (小有名气)
引用回帖:
5楼: Originally posted by aircraftvip at 2013-12-09 17:55:37
''Tissue is much more transparent at longer wavelengths (~700–850 nm). Absorbing at longer wavelengths would allow the light to penetrate deeper, and allow the treatment of larger tumors.''- wikiped ...

这文献是搞计算啊，没怎么看懂，呵呵，是不是说每个波长匹配都可以产生单线态氧。？
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赶紧毕业
6楼2013-12-10 09:06:57
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aircraftvip

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引用回帖:
6楼: Originally posted by vwangvhaov at 2013-12-10 09:06:57
这文献是搞计算啊，没怎么看懂，呵呵，是不是说每个波长匹配都可以产生单线态氧。？...

You may read the phtotophysics and photochemistry part in this review:

Mechanisms in photodynamic therapy:
part one—–photosensitizers, photochemistry
and cellular localization

Photodiagnosis and photodynamic Therapy (2004) 1, 279—293
http://www.sciencedirect.com/sci ... i/S1572100005000074
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vwangvhaov
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7楼2013-12-11 23:28:38
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vwangvhaov

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送红花一朵
引用回帖:
7楼: Originally posted by aircraftvip at 2013-12-11 23:28:38
You may read the phtotophysics and photochemistry part in this review:

Mechanisms in photodynamic therapy:
part one—–photosensitizers, photochemistry
and cellular localization

Photodiagnos ...

感谢！老师能否留下QQ，我好向您多请教！
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赶紧毕业
8楼2013-12-12 16:10:22
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