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vwangvhaov木虫 (小有名气)
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[求助]
光敏剂波长匹配求助
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二氢卟吩e6这种光敏剂在400nm与660nm有吸收峰，目前文献中都是应用660nm进行光动力产生单线态氧。用400nm的从没有见过。大虾们能否告诉我400nm如果有波长匹配的话，是否能在400nm出激发产生单线态氧呢？？？ 感谢！ |
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pepperp
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2楼2013-12-09 16:50:10
vwangvhaov
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''Tissue is much more transparent at longer wavelengths (~700–850 nm). Absorbing at longer wavelengths would allow the light to penetrate deeper, and allow the treatment of larger tumors.''- wikipedia J Biomed Opt. 2012 Aug;17(8):088001-1. doi: 10.1117/1.JBO.17.8.088001. Comparison of photodynamic therapy with different excitation wavelengths using a dynamic model of aminolevulinic acid-photodynamic therapy of human skin. Liu B, Farrell TJ, Patterson MS. Source McMaster University, Department of Medical Physics and Applied Radiation Sciences, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4K1. Abstract Different wavelength light sources are used in photodynamic therapy (PDT) of the skin to treat different conditions. Clinical studies show inconsistent results for the effectiveness of aminolevulinic acid (ALA)-PDT performed at different wavelengths. In order to understand the effect of treatment wavelength, a theoretical study was performed to calculate time-resolved depth-dependent distributions of PDT components including ground-state oxygen, sensitizer, and reacted singlet oxygen for different treatment wavelengths (405, 523, and 633 nm) using a numerical model of ALA-PDT of human skin. This model incorporates clinically relevant features of the PDT process including light attenuation, photobleaching, oxygen consumption, and diffusion, as well as tissue perfusion. The calculations show that the distributions of these quantities are almost independent of the treatment wavelength to a depth of about 1 mm. In this surface region, PDT-induced hypoxia is the dominant process. At greater depths, the production of singlet -oxygen is governed by the penetration of the treatment light. Two noninvasive PDT dosimetry approaches: the cumulative singlet oxygen luminescence (CSOL) and the fractional fluorescence bleaching metric, were investigated and compared for all three wavelengths. Although CSOL was more robust, both metrics provided correlations with the singlet oxygen dose in the upper dermis that were almost independent of treatment wavelength. This relationship breaks down at greater depths because light penetration depends on wavelength. |
5楼2013-12-09 17:55:37
vwangvhaov
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You may read the phtotophysics and photochemistry part in this review: Mechanisms in photodynamic therapy: part one—–photosensitizers, photochemistry and cellular localization Photodiagnosis and photodynamic Therapy (2004) 1, 279—293 http://www.sciencedirect.com/sci ... i/S1572100005000074 |
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vwangvhaov7楼2013-12-11 23:28:38
vwangvhaov
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8楼2013-12-12 16:10:22
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