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【答案】应助回帖
★ ★
yaolan123: 金币+2, 感谢应助，奖励一下 2013-11-08 14:08:10
jssxh: 检索EPI+1, 谢谢参与，请继续关注本版块！ 2013-12-16 09:21:53
1.
http://apps.webofknowledge.com/f ... age=1&doc=1
PREPARATION AND CHARACTERIZATION OF GLYCYRRHETINIC ACID-MODIFIED POLOXAMER 188/CHITOSAN NANOPARTICLES
作者: Wang, J (Wang, Jing)[ 1 ] ; Guo, L (Guo, Li)[ 2 ] ; Ma, LF (Ma, Li Fang)[ 1 ]
来源出版物: NANO 卷:8 期:4 文献号:1350042 DOI:10.1142/S1793292013500422 出版年:AUG 2013
被引频次: 0 (来自 Web of Science)
引用的参考文献: 12 [ 查看 Related Records ] 引证关系图
摘要: In this paper, we firstly synthesized glycyrrhetinic acid-modified double amino-terminated poloxamer 188 (GA-NH-POLO-NH-GA). The structure of the synthesized compound was confirmed by 1 H-NMR and Fourier transform infrared (FT-IR) spectroscopy. Then the nano-particles composed of GA-NH-POLO-NH-GA/chitosan (GA-NH-POLO-NH-GA/CTS) were prepared by an ionic gelation process. The characterization of the nanoparticles was measured by dynamic light scattering (DLS) and scanning electron microscope (SEM). The results showed that the nanoparticles were well dispersed with a spherical shape and the particle size was distributed between 100 nm and 300 nm. The cytotoxicity based on MTT assay against cells (QGY-7703 cells and L929 cells) showed that the nanoparticles had low toxicity and good biocompatibility. The encapsulation efficiency and drug loading of 5-fluorouracil-loaded nanoparticles (5-FU nanoparticles) were measured by high-performance liquid chromatography (HPLC) and fluorescence spectroscopy, ultraviolet-visible (UV-vis) absorbance. The encapsulation of 5-Fu-loaded CTS nanoparticles was 12.8% and the drug loading was 2.9%, while the encapsulation of 5-Fu-loaded GA-NH-POLO-NH-GA/CTS nanoparticles was 20.9% and the drug loading was 3.36%. The release profile showed that the GA-NH-POLO-NH-GA/CTS nanoparticles were available for sustained release of 5-Fu. The GA-NH-POLO-NH-GA/CTS nanoparticles have a higher affinity to the QGY-7703 cells, so indicated that the GA-NH-POLO-NH-GA/CTS nanoparticles have the capacity of liver-targeting in vitro.
入藏号:WOS:000321954700009
文献类型: Article
语种: English
作者关键词: Glycyrrhetinic acid; poloxamer 188; chitosan; nanoparticles; sustained release; liver-targeting
KeyWords Plus: CANCER-THERAPY; CHITOSAN
通讯作者地址: Ma, LF (通讯作者)
Sichuan Univ, Dept Pharmaceut & Biol Engn, Chengdu 610065, Peoples R China.
地址:
[ 1 ] Sichuan Univ, Dept Pharmaceut & Biol Engn, Chengdu 610065, Peoples R China
[ 2 ] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Dept Med Chem,West China Sch Pharm, Chengdu 610041, Peoples R China
电子邮件地址: wangjingrose3@163.com; rosaguoli2000@yahoo.com.cn; MLfang11@126.com
出版商:WORLD SCIENTIFIC PUBL CO PTE LTD, 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
Web of Science 类别: Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
研究方向: Science & Technology - Other Topics; Materials Science; Physics
IDS 号:185GJ
ISSN:1793-2920 |
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