| 查看: 3990 | 回复: 68 | |||||
[交流]
【2013-12-31】Frontiers in Microbiology专刊征稿【SCIE】
|
|||||
DNA Replication Origins in Microbial Genomes 导师主持的专刊，如有合适的工作，欢迎各位投稿。如有兴趣，可站内信联系。 http://www.frontiersin.org/evolu ... origins_in_mic/2193 In collaboration with Frontiers in Microbiology, we are organizing a Research Topic titled "DNA Replication Origins in Microbial Genomes”. Frontiers, a Swiss open-access publisher, recently partnered with Nature Publishing Group to expand its researcher-driven Open Science platform. Frontiers articles are rigorously peer-reviewed, can be disseminated freely and are widely read by your colleagues and by the broader scientific and medical research communities. Research Topic DNA replication, a central event for cell proliferation, is the basis of biological inheritance. Complete and accurate DNA replication is integral to the maintenance of the genetic integrity of organisms. In all three domains of life, DNA replication begins at replication origins. In bacteria, replication initiates from a single replication origin (oriC), which contains several DnaA boxes. In eukaryotic genomes, replication initiates from significantly more replication origins, ranging from hundreds in yeast to tens of thousands in human, activated simultaneously at a specific time. For eukaryotic organisms, replication origins are best characterized in the unicellular eukaryote budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. The budding yeast origins contain an essential sequence element called the ARS (autonomously replicating sequence), while the fission yeast origins consist of AT-rich sequences. Within the archaeal domain, the multiple replication origins have been identified by a predict-and-verify approach in the hyperthermophilic archaeon Sulfolobus. Archaeal origins contain two or more short repetitive DNA sequences, known as origin recognition boxes (ORBs). It appears that archaea have a simplified version of the eukaryotic replication apparatus, which has led to considerable interest in the archaeal machinery as a model of that in eukaryotes. The identification of replication origins is important not only in providing insights into the structure and function of the replication origins but also in understanding the regulatory mechanisms of the initiation step in DNA replication. Therefore, intensive studies have been carried out on the identification of replication origins in the last two decades. The pioneer work to identify bacterial oriCs in silico is the GC-skew analysis. Later, a method of cumulative GC skew without sliding windows was proposed to give better resolution. Meanwhile, an oligomer-skew method was also proposed to predict oriC regions in bacterial genomes. As a unique representation of a DNA sequence, the Z-curve method has been proved to be an accurate and effective approach to predict bacterial and archaeal replication origins. Budding yeast origins have been predicted by Oriscan using similarity to the characterized ones, while the fission yeast origins have been indentified initially from AT content calculation. In comparison with the in silico analysis, the experimental methods are convincing and reliable, but time-consuming and labor-intensive. The microbial replication origins can be identified by several experimental methods including construction of replicative oriC plasmids, microarray-based or high-throughput sequencing-based marker frequency analysis, two-dimensional gel electrophoresis analysis and replication initiation point mapping (RIP mapping) etc. The recent genome-wide approaches to identify and characterize replication origin locations have boosted the number of mapped yeast replication origins. The availability of increasing complete microbial genomes and emerging approaches has created challenges and opportunities for identification of their replication origins in silico, as well as in vivo. This research topic invites for the studies of microbial replication origins, addressing all the issues mentioned above, by in silico analyses as well as in vivo experiments. Manuscripts describing original research, methods, opinions, reviews are all welcome, which would provide a comprehensive overview of this field. [ Last edited by 流风易逝 on 2013-11-4 at 12:03 ] |
回复此楼» 猜你喜欢
工科材料085601 279求调剂
已经有8人回复
-
317求调剂
已经有8人回复
-
一志愿南昌大学，327分，材料与化工085600
已经有5人回复
-
274求调剂
已经有7人回复
-
317求调剂
已经有9人回复
-
招收调剂硕士
已经有11人回复
-
286分人工智能专业请求调剂愿意跨考！
已经有4人回复
-
【考研调剂】化学专业 281分，一志愿四川大学，诚心求调剂
已经有6人回复
-
一志愿吉林大学材料学硕321求调剂
已经有14人回复
-
材料学硕297已过四六级求调剂推荐
已经有5人回复
» 抢金币啦！回帖就可以得到:
-
绍兴大学博士教师招聘1位（化学化工相关）
+5/295
-
广东工业大学-木质纤维素高值化利用团队招博士研究生
+1/96
-
有没有在香港的虫友啊
+1/75
-
西北大学化学与材料科学学院博士招生（还有两个名额，3月30日截至）
+1/64
-
飘在美国，有点想家
+1/53
-
福建师范大学闽江学者陈巍教授团队招收2026年化学、化工或材料专业的学硕6名
+1/38
-
0854电子信息调剂，闽南师大光电芯片研发实验室，柯少颖教授课题组，集成电路
+1/36
-
哈工大郑州高等研究院刘绍琴与查正宝教授课题组诚招合成生物学背景相关的优秀人才加盟
+1/34
-
上海交通大学沈道智副教授招收2026年联培博士/硕士研究生（微纳器件与制造方向）
+1/33
-
深圳信息职业大学招聘联合培养硕博研究生（急）
+1/18
-
重庆文理学院化学与环境工程学院 2026 届硕士研究生调剂通知
+1/15
-
南京林业大学有机功能分子实验室博士生招生启事
+1/8
-
教育部长江学者和创新团队发展计划”入选团队招收 材料，化学与化工博士研究生
+1/7
-
211/双一流---石河子大学---有机化学方向招调剂生
+1/7
-
中国科学院过程工程研究所助理研究员（正式职工）和博士后招聘启事
+1/4
-
招收化工与材料学科点研究生
+1/4
-
南京林业大学木质纤维功能材料国际联合创新中心招收2026级博士生（申请-考核制）
+2/4
-
镇江托尔化学有机合成研发岗位工作机会
+1/3
-
海外博士招聘
+1/2
-
125603工业工程与管理调剂
+1/1
7楼2013-11-04 12:18:16
9楼2013-11-04 12:19:17
10楼2013-11-04 12:19:31
11楼2013-11-04 12:20:29
21楼2013-11-04 12:36:25
37楼2013-11-04 13:00:54
38楼2013-11-04 13:01:54
简单回复
haixiawu2楼
2013-11-04 12:00
流风易逝(金币+1): 谢谢参与
2013-11-04 12:15
流风易逝(金币+1): 谢谢参与
沧__海4楼
2013-11-04 12:16
流风易逝(金币+1): 谢谢参与
2013-11-04 12:17
流风易逝(金币+1): 谢谢参与
2013-11-04 12:17
流风易逝(金币+1): 谢谢参与
2013-11-04 12:18
流风易逝(金币+1): 谢谢参与
7
clarktao12楼
2013-11-04 12:20
流风易逝(金币+1): 谢谢参与
kaye63913楼
2013-11-04 12:22
流风易逝(金币+1): 谢谢参与
xiaomu7814楼
2013-11-04 12:24
流风易逝(金币+1): 谢谢参与
florahdu15楼
2013-11-04 12:26
流风易逝(金币+1): 谢谢参与
liulinkk16楼
2013-11-04 12:26
流风易逝(金币+1): 谢谢参与
天涯201217楼
2013-11-04 12:27
流风易逝(金币+1): 谢谢参与
miaojiabing18楼
2013-11-04 12:27
流风易逝(金币+1): 谢谢参与
求不重复19楼
2013-11-04 12:31
流风易逝(金币+1): 谢谢参与
paperhunter20楼
2013-11-04 12:35
流风易逝(金币+1): 谢谢参与
wangjingrui22楼
2013-11-04 12:37
流风易逝(金币+1): 谢谢参与
至尊山羊23楼
2013-11-04 12:38
流风易逝(金币+1): 谢谢参与
supervb24楼
2013-11-04 12:39
流风易逝(金币+1): 谢谢参与
落花剑雨25楼
2013-11-04 12:43
流风易逝(金币+1): 谢谢参与
杰克小龙26楼
2013-11-04 12:44
流风易逝(金币+1): 谢谢参与
xiejf27楼
2013-11-04 12:45
流风易逝(金币+1): 谢谢参与
huigoo28楼
2013-11-04 12:45
流风易逝(金币+1): 谢谢参与
张鑫198229楼
2013-11-04 12:45
流风易逝(金币+1): 谢谢参与
lonelyhere30楼
2013-11-04 12:47
流风易逝(金币+1): 谢谢参与
huigoo31楼
2013-11-04 12:48
尘轩无梦32楼
2013-11-04 12:50
流风易逝(金币+1): 谢谢参与
。 [ 发自手机版 http://muchong.com/3g ]
chenyh71833楼
2013-11-04 12:54
流风易逝(金币+1): 谢谢参与
1 [ 发自手机版 http://muchong.com/3g ]
JOEF34楼
2013-11-04 12:56
流风易逝(金币+1): 谢谢参与
！ [ 发自手机版 http://muchong.com/3g ]
裤兜有烟35楼
2013-11-04 12:57
流风易逝(金币+1): 谢谢参与
xianzhi201036楼
2013-11-04 12:59
流风易逝(金币+1): 谢谢参与
zhoupeng8739楼
2013-11-04 13:03
流风易逝(金币+1): 谢谢参与
·
木米月厷40楼
2013-11-04 13:04
流风易逝(金币+1): 谢谢参与
taochao41楼
2013-11-04 13:07
流风易逝(金币+1): 谢谢参与
yuyu860242楼
2013-11-04 13:08
流风易逝(金币+1): 谢谢参与
zbdfwq577743楼
2013-11-04 13:13
流风易逝(金币+1): 谢谢参与
liang888744楼
2013-11-04 13:15
流风易逝(金币+1): 谢谢参与
MRU烟气专家45楼
2013-11-04 13:20
流风易逝(金币+1): 谢谢参与
放大镜46楼
2013-11-04 13:41
流风易逝(金币+1): 谢谢参与
mv47楼
2013-11-04 13:47
流风易逝(金币+1): 谢谢参与
icebergwu48楼
2013-11-04 13:53
流风易逝(金币+1): 谢谢参与
aboluo19833149楼
2013-11-04 13:58
流风易逝(金币+1): 谢谢参与
laosi50950楼
2013-11-04 14:02
流风易逝(金币+1): 谢谢参与
