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[求助]
求助默克索引相关信息，谢谢大家
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求助默克索引相关信息，谢谢大家，可追加金币： 英文通用名：Ixabepilone 中文通用名：伊沙匹隆 商品名： Ixempra CAS登录号：219989-84-1 |
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哲凝: 金币+10, ★★★很有帮助, 谢谢 2013-09-16 22:22:52
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Title: Ixabepilone CAS Registry Number: 219989-84-1 CAS Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione Additional Names: azaepothilone B Manufacturers' Codes: BMS-247550; NSC-710428 Molecular Formula: C27H42N2O5S Molecular Weight: 506.70 Percent Composition: C 64.00%, H 8.35%, N 5.53%, O 15.79%, S 6.33% Literature References: Microtubule stabilizing semisynthetic lactam analog of epothilone B, q.v. Prepn: G. D. Vite et al., WO 9902514; eidem, US 6605599 (1999, 2003 both to Bristol-Myers Squibb); R. M. Borzilleri et al., J. Am. Chem. Soc. 122, 8890 (2000). Antineoplastic activity in vitro and in vivo: F. Y. F. Lee et al., Clin. Cancer Res. 7, 1429 (2001). Clinical evaluation with estramustine in prostate cancer: J. E. Rosenberg et al., Cancer 106, 58 (2006). Clinical pharmacokinetics and evaluation in solid tumors: S. Mani et al., Clin. Cancer Res. 10, 1289 (2004). Clinical evaluation in breast cancer: J. A. Low et al., J. Clin. Oncol. 23, 2726 (2005); in prostate cancer: M. Hussain et al., ibid. 8724. Review of pharmacology and clinical development: N. Lin et al., Curr. Opin. Invest. Drugs 4, 746-756 (2003). Properties: Colorless oil or white lyopholizate; [a]D22 -40.7° (c = 1.0 in chloroform). Optical Rotation: [a]D22 -40.7° (c = 1.0 in chloroform) Therap-Cat: Antineoplastic. Keywords: Antineoplastic; Alkaloids/Natural Products. |
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