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[资源] Adverse Drug Reactions

Sample Text
Jack Uetrecht Editor

隶属于Handbook of Experimental Pharmacology
Volume 196
Editor-in-Chief
F.B. Hofmann, München

ISSN 0171-2004 e-ISSN 1865-0325
ISBN 978-3-642-00662-3 e-ISBN 978-3-642-00663-0
DOI: 10.1007/978-3-642-00663-0
Springer Heidelberg Dordrecht London New York

Contents
Part I Target Organ Toxicity
1 Drug-Induced Liver Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Michael Holt and Cynthia Ju
2 Drug Hypersensitivity Reactions Involving Skin . . . . . . . . . . . . . . . . . . . . . . . . 29
Oliver Hausmann, Benno Schnyder, and Werner J. Pichler
3 Adverse Drug Reactions Affecting Blood Cells . . . . . . . . . . . . . . . . . . . . . . . . . 57
Richard H. Aster
4 Molecular Mechanisms of Adverse Drug Reactions
in Cardiac Tissue . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Reza Tabrizchi
5 Mechanisms of Drug-Induced Nephrotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . 111
Thomas D. Nolin and Jonathan Himmelfarb
6 Receptor- and Reactive Intermediate-Mediated Mechanisms
of Teratogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
Peter G. Wells, Crystal J.J. Lee, Gordon P. McCallum,
Julia Perstin, and Patricia A. Harper
Part II Mediators/Biochemical Pathways
7 Role of Reactive Metabolites in Drug-Induced Hepatotoxicity . . . . . . 165
Srivastava A., Maggs J.L., Antoine D.J., Williams D.P.,
Smith D.A., and Park B.K.
8 The Role of Cytokines in the Mechanism of Adverse
Drug Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195
Mary Jane Masson, Lindsay A. Collins, and Lance R. Pohl
vii
9 The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms
of Regulation and Role in Protection Against
Drug-Induced Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham,
and B. Kevin Park
10 Signal Transduction Pathways Involved in Drug-Induced
Liver Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267
Derick Han, Mie Shinohara, Maria D. Ybanez, Behnam Saberi,
and Neil Kaplowitz
11 Mitochondrial Involvement in Drug-Induced Liver Injury . . . . . . . . . . 311
Dominique Pessayre, Abdellah Mansouri, Alain Berson,
and Bernard Fromenty
Part III Examples/Models
12 Mechanisms of Acetaminophen-Induced Liver Necrosis . . . . . . . . . . . . . 369
Jack A. Hinson, Dean W. Roberts, and Laura P. James
13 Drug-Induced Liver Injury in Humans: The Case
of Ximelagatran . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 407
M. Keisu and T. B. Andersson
14 Troglitazone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419
Tsuyoshi Yokoi
15 Nevirapine Hypersensitivity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 437
M. Popovic, J.M. Shenton, J. Chen, A. Baban,
T. Tharmanathan, B. Mannargudi, D. Abdulla, and J.P. Uetrecht
16 Mechanisms of Adverse Drug Reactions to Biologics . . . . . . . . . . . . . . . . . 453
Janet B. Clarke
Part IV Risk Factors/Screening Drug Candidates
17 Pharmacogenetics of Idiosyncratic Adverse Drug Reactions . . . . . . . . 477
Munir Pirmohamed
18 The Danger Hypothesis Applied to Idiosyncratic Drug Reactions . . . . 493
Jinze Li and Jack P. Uetrecht
19 Approaches for Minimizing Metabolic Activation
of New Drug Candidates in Drug Discovery . . . . . . . . . . . . . . . . . . . . . . . . . . 511
Sanjeev Kumar, Kaushik Mitra, Kelem Kassahun, and Thomas A. Baillie
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 545

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