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±êÌâ: Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters
×÷Õß: Liu, Chang-Xiao; Yi, Xiu-Lin; Si, Duan-Yun; µÈ.
À´Ô´³ö°æÎï: CURRENT DRUG METABOLISM  ¾í: 12   ÆÚ: 9   Ò³: 835-849   ³ö°æÄê: NOV 2011
±»ÒýƵ´Î: 7 (À´×Ô Web of Science)
1.
±êÌâ: Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: Application to a drug-drug interaction study in Radix Polygoni Multiflori
×÷Õß: Ma, Jiang; Zheng, Li; Deng, Ting; µÈ.
À´Ô´³ö°æÎï: JOURNAL OF ETHNOPHARMACOLOGY  ¾í: 147   ÆÚ: 2   Ò³: 335-340   DOI: 10.1016/j.jep.2013.03.013   ³ö°æÄê: MAY 20 2013
±»ÒýƵ´Î: 0 (À´×Ô Web of Science)
  [  ²é¿´ÕªÒª ]
2.
±êÌâ: Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions
×÷Õß: Zhu, Qiong-Ni; Zhang, Dan; Jin, Tao; µÈ.
À´Ô´³ö°æÎï: JOURNAL OF ETHNOPHARMACOLOGY  ¾í: 147   ÆÚ: 1   Ò³: 215-219   DOI: 10.1016/j.jep.2013.03.005   ³ö°æÄê: MAY 2 2013
±»ÒýƵ´Î: 0 (À´×Ô Web of Science)
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3.
±êÌâ: THE ROLE OF OATPS IN PHARMACOKINETICS AND DRUG-DRUG INTERACTIONS OF CARDIOVASCULAR AGENTS
×÷Õß: Wen, J. H.; Wu, W.; Yang, D.; µÈ.
À´Ô´³ö°æÎï: DRUGS OF THE FUTURE  ¾í: 38   ÆÚ: 4   Ò³: 257-262   DOI: 10.1358/dof.2013.38.4.1906426   ³ö°æÄê: APR 2013
±»ÒýƵ´Î: 0 (À´×Ô Web of Science)
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4.
±êÌâ: Shared Decision Making in Complementary and Alternative Medicine Therapies
×÷Õß: Jansons, Lauren L.; Lynch, Rachel L.; LeBlanc, Annie; µÈ.
À´Ô´³ö°æÎï: PEDIATRIC ANNALS  ¾í: 41   ÆÚ: 12   Ò³: 522-527   DOI: 10.3928/00904481-20121126-14   ³ö°æÄê: DEC 2012
±»ÒýƵ´Î: 0 (À´×Ô Web of Science)
  5.
±êÌâ: Absorption and Interaction of the Main Constituents from the Traditional Chinese Drug Pair Shaoyao-Gancao via a Caco-2 Cell Monolayer Model
×÷Õß: Chen, Yan; Wang, Jinyan; Wang, Lu; µÈ.
À´Ô´³ö°æÎï: MOLECULES  ¾í: 17   ÆÚ: 12   Ò³: 14908-14917   DOI: 10.3390/molecules171214908   ³ö°æÄê: DEC 2012
±»ÒýƵ´Î: 0 (À´×Ô Web of Science)
  [  ²é¿´ÕªÒª ]
6.
±êÌâ: Theranostics meets traditional Chinese medicine: rational prediction of drug-herb interactions
×÷Õß: Hu, Miao; Fan, Lan; Zhou, Hong-Hao; µÈ.
À´Ô´³ö°æÎï: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS  ¾í: 12   ÆÚ: 8   Ò³: 815-830   DOI: 10.1586/ERM.12.126   ³ö°æÄê: NOV 2012
±»ÒýƵ´Î: 1 (À´×Ô Web of Science)
[  ²é¿´ÕªÒª ]
7.
±êÌâ: Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?
×÷Õß: Yu, Ke; Chen, Feng; Li, Chuan
À´Ô´³ö°æÎï: CURRENT DRUG METABOLISM  ¾í: 13   ÆÚ: 5   Ò³: 577-598   ³ö°æÄê: JUN 2012
±»ÒýƵ´Î: 8 (À´×Ô Web of Science)
[  ²é¿´ÕªÒª ]
4Â¥2013-07-05 16:00:15
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Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters  
Author(s): Liu, CX (Liu, Chang-Xiao)[ 1 ] ; Yi, XL (Yi, Xiu-Lin)[ 1 ] ; Si, DY (Si, Duan-Yun)[ 1 ] ; Xiao, XF (Xiao, Xue-Feng)[ 1,2 ] ; He, X (He, Xin)[ 2 ] ; Li, YZ (Li, Ya-Zhuo)[ 1 ]  
Source: CURRENT DRUG METABOLISM  Volume: 12   Issue: 9   Pages: 835-849   Published: NOV 2011  
Times Cited: 7 (from Web of Science)  
Cited References: 128      [ view related records ]     Citation Map      
Abstract: Herbal medicines and their active ingredients are widely used worldwide, and they have become an important part of clinical medicine. The combined use of herbs and drugs has increased the possibility of pharmacokinetic and pharmacodynamic interactions. Clinical studies have demonstrated that the combined use of herbs and drugs can enhance or attenuate the drug efficacy and toxicity. The herb-drug combinations may reduce a drug efficacy and lead to treatment failure when long-term administration. Case reports detailing serious clinical adverse reactions have promoted studies on the interactions between herbs and drugs. This review highlights recent knowledge to discuss herb-drug interactions involving metabolizing enzymes and drug transporters. Drug transporters are widely present in body and play an important role in the absorption, distribution, excretion and metabolism, efficacy, and toxicity of drugs. Investigation of transporters has developed rapidly since 1990s, the effects of many transporters on the pharmacokinetics of drugs and herb-drug interactions have been reported. Some concepts on drug transporters issued experimentally and clinically drug-drug and herb-drug interactions have applied in many studies. Methodology studies are very important for understanding the mechanism, considerations and evaluation of experiments and clinical studies on drug metabolizing enzymes and transporters in drug-drug interactions.  
Accession Number: WOS:000299670700005  
Document Type: Review  
Language: English  
Author Keywords: Drug-drug interaction; herbal medicines; herb-drug interactions; metabolizing enzymes; transporter  
KeyWords Plus: ST-JOHNS-WORT; IN-VIVO ASSESSMENT; P-GLYCOPROTEIN; HEALTHY-VOLUNTEERS; GRAPEFRUIT JUICE; GINKGO-BILOBA; PHARMACOKINETIC INTERACTIONS; SALVIA-MILTIORRHIZA; CYTOCHROME-P450 3A; GARLIC SUPPLEMENTS  
Reprint Address: Liu, CX (reprint author)        Tianjin Inst Pharmaceut Res, Key Lab Drug Delivery Technol & Pharmacokinet, Tianjin 300193, Peoples R China.

Addresses:        [ 1 ] Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China
       [ 2 ] Tianjin Univ Tradit Med, Coll Chinese Meteria Med, Tianjin 300193, Peoples R China

E-mail Addresses: liuchangxiao@163.com  
Funding:
Funding Agency Grant Number
National Basic Research Plan (973 Plan) Foundation of China  2010CB735602  
National Innovation Plan for New Drugs  2009ZX09304-002
2009ZX09304-005  
Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)   
National Nature Foundation of China  30973932
30772778  
Doctoral Special Project Foundation of China Universities  20070063001  

[Show funding text][Hide funding text]   

This review is financially supported by the fund of National Basic Research Plan (973 Plan) Foundation of China (Grant No. 2010CB735602), National Innovation Plan for New Drugs (Grant No. 2009ZX09304-002 and 2009ZX09304-005), Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT), National Nature Foundation of China (Grant No. 30973932 and 30772778) and Doctoral Special Project Foundation of China Universities (Grant No. 20070063001).

Publisher: BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES  
Web of Science Categories: Biochemistry & Molecular Biology; Pharmacology & Pharmacy  
Research Areas: Biochemistry & Molecular Biology; Pharmacology & Pharmacy  
IDS Number: 883YG  
ISSN: 1389-2002
5Â¥2013-07-05 17:06:50
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5Â¥: Originally posted by nuaawq at 2013-07-05 17:06:50
Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters  
Author(s): Liu, CX (Liu, Chang-Xiao) ; Yi, XL (Yi, Xiu-Lin) ; Si, DY (Si, Duan-Yun) ; Xiao, XF (Xiao, Xue-Feng) ; He, X  ...

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