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±êÌâ: Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters ×÷Õß: Liu, Chang-Xiao; Yi, Xiu-Lin; Si, Duan-Yun; µÈ. À´Ô´³ö°æÎï: CURRENT DRUG METABOLISM ¾í: 12 ÆÚ: 9 Ò³: 835-849 ³ö°æÄê: NOV 2011 ±»ÒýƵ´Î: 7 (À´×Ô Web of Science) 1. ±êÌâ: Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: Application to a drug-drug interaction study in Radix Polygoni Multiflori ×÷Õß: Ma, Jiang; Zheng, Li; Deng, Ting; µÈ. À´Ô´³ö°æÎï: JOURNAL OF ETHNOPHARMACOLOGY ¾í: 147 ÆÚ: 2 Ò³: 335-340 DOI: 10.1016/j.jep.2013.03.013 ³ö°æÄê: MAY 20 2013 ±»ÒýƵ´Î: 0 (À´×Ô Web of Science) [ ²é¿´ÕªÒª ] 2. ±êÌâ: Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions ×÷Õß: Zhu, Qiong-Ni; Zhang, Dan; Jin, Tao; µÈ. À´Ô´³ö°æÎï: JOURNAL OF ETHNOPHARMACOLOGY ¾í: 147 ÆÚ: 1 Ò³: 215-219 DOI: 10.1016/j.jep.2013.03.005 ³ö°æÄê: MAY 2 2013 ±»ÒýƵ´Î: 0 (À´×Ô Web of Science) [ ²é¿´ÕªÒª ] 3. ±êÌâ: THE ROLE OF OATPS IN PHARMACOKINETICS AND DRUG-DRUG INTERACTIONS OF CARDIOVASCULAR AGENTS ×÷Õß: Wen, J. H.; Wu, W.; Yang, D.; µÈ. À´Ô´³ö°æÎï: DRUGS OF THE FUTURE ¾í: 38 ÆÚ: 4 Ò³: 257-262 DOI: 10.1358/dof.2013.38.4.1906426 ³ö°æÄê: APR 2013 ±»ÒýƵ´Î: 0 (À´×Ô Web of Science) [ ²é¿´ÕªÒª ] 4. ±êÌâ: Shared Decision Making in Complementary and Alternative Medicine Therapies ×÷Õß: Jansons, Lauren L.; Lynch, Rachel L.; LeBlanc, Annie; µÈ. À´Ô´³ö°æÎï: PEDIATRIC ANNALS ¾í: 41 ÆÚ: 12 Ò³: 522-527 DOI: 10.3928/00904481-20121126-14 ³ö°æÄê: DEC 2012 ±»ÒýƵ´Î: 0 (À´×Ô Web of Science) 5. ±êÌâ: Absorption and Interaction of the Main Constituents from the Traditional Chinese Drug Pair Shaoyao-Gancao via a Caco-2 Cell Monolayer Model ×÷Õß: Chen, Yan; Wang, Jinyan; Wang, Lu; µÈ. À´Ô´³ö°æÎï: MOLECULES ¾í: 17 ÆÚ: 12 Ò³: 14908-14917 DOI: 10.3390/molecules171214908 ³ö°æÄê: DEC 2012 ±»ÒýƵ´Î: 0 (À´×Ô Web of Science) [ ²é¿´ÕªÒª ] 6. ±êÌâ: Theranostics meets traditional Chinese medicine: rational prediction of drug-herb interactions ×÷Õß: Hu, Miao; Fan, Lan; Zhou, Hong-Hao; µÈ. À´Ô´³ö°æÎï: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS ¾í: 12 ÆÚ: 8 Ò³: 815-830 DOI: 10.1586/ERM.12.126 ³ö°æÄê: NOV 2012 ±»ÒýƵ´Î: 1 (À´×Ô Web of Science) [ ²é¿´ÕªÒª ] 7. ±êÌâ: Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More? ×÷Õß: Yu, Ke; Chen, Feng; Li, Chuan À´Ô´³ö°æÎï: CURRENT DRUG METABOLISM ¾í: 13 ÆÚ: 5 Ò³: 577-598 ³ö°æÄê: JUN 2012 ±»ÒýƵ´Î: 8 (À´×Ô Web of Science) [ ²é¿´ÕªÒª ] |
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Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters Author(s): Liu, CX (Liu, Chang-Xiao)[ 1 ] ; Yi, XL (Yi, Xiu-Lin)[ 1 ] ; Si, DY (Si, Duan-Yun)[ 1 ] ; Xiao, XF (Xiao, Xue-Feng)[ 1,2 ] ; He, X (He, Xin)[ 2 ] ; Li, YZ (Li, Ya-Zhuo)[ 1 ] Source: CURRENT DRUG METABOLISM Volume: 12 Issue: 9 Pages: 835-849 Published: NOV 2011 Times Cited: 7 (from Web of Science) Cited References: 128 [ view related records ] Citation Map Abstract: Herbal medicines and their active ingredients are widely used worldwide, and they have become an important part of clinical medicine. The combined use of herbs and drugs has increased the possibility of pharmacokinetic and pharmacodynamic interactions. Clinical studies have demonstrated that the combined use of herbs and drugs can enhance or attenuate the drug efficacy and toxicity. The herb-drug combinations may reduce a drug efficacy and lead to treatment failure when long-term administration. Case reports detailing serious clinical adverse reactions have promoted studies on the interactions between herbs and drugs. This review highlights recent knowledge to discuss herb-drug interactions involving metabolizing enzymes and drug transporters. Drug transporters are widely present in body and play an important role in the absorption, distribution, excretion and metabolism, efficacy, and toxicity of drugs. Investigation of transporters has developed rapidly since 1990s, the effects of many transporters on the pharmacokinetics of drugs and herb-drug interactions have been reported. Some concepts on drug transporters issued experimentally and clinically drug-drug and herb-drug interactions have applied in many studies. Methodology studies are very important for understanding the mechanism, considerations and evaluation of experiments and clinical studies on drug metabolizing enzymes and transporters in drug-drug interactions. Accession Number: WOS:000299670700005 Document Type: Review Language: English Author Keywords: Drug-drug interaction; herbal medicines; herb-drug interactions; metabolizing enzymes; transporter KeyWords Plus: ST-JOHNS-WORT; IN-VIVO ASSESSMENT; P-GLYCOPROTEIN; HEALTHY-VOLUNTEERS; GRAPEFRUIT JUICE; GINKGO-BILOBA; PHARMACOKINETIC INTERACTIONS; SALVIA-MILTIORRHIZA; CYTOCHROME-P450 3A; GARLIC SUPPLEMENTS Reprint Address: Liu, CX (reprint author) Tianjin Inst Pharmaceut Res, Key Lab Drug Delivery Technol & Pharmacokinet, Tianjin 300193, Peoples R China. Addresses: [ 1 ] Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin 300193, Peoples R China [ 2 ] Tianjin Univ Tradit Med, Coll Chinese Meteria Med, Tianjin 300193, Peoples R China E-mail Addresses: liuchangxiao@163.com Funding: Funding Agency Grant Number National Basic Research Plan (973 Plan) Foundation of China 2010CB735602 National Innovation Plan for New Drugs 2009ZX09304-002 2009ZX09304-005 Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) National Nature Foundation of China 30973932 30772778 Doctoral Special Project Foundation of China Universities 20070063001 [Show funding text][Hide funding text] This review is financially supported by the fund of National Basic Research Plan (973 Plan) Foundation of China (Grant No. 2010CB735602), National Innovation Plan for New Drugs (Grant No. 2009ZX09304-002 and 2009ZX09304-005), Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT), National Nature Foundation of China (Grant No. 30973932 and 30772778) and Doctoral Special Project Foundation of China Universities (Grant No. 20070063001). Publisher: BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES Web of Science Categories: Biochemistry & Molecular Biology; Pharmacology & Pharmacy Research Areas: Biochemistry & Molecular Biology; Pharmacology & Pharmacy IDS Number: 883YG ISSN: 1389-2002 |
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