24小时热门版块排行榜

返回列表

本帖产生 1 个翻译EPI ，点击这里进行查看

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

hanshuang

金虫 (著名写手)

应助: 16 (小学生)
金币: 1168.8
散金: 66
帖子: 1089
在线: 27.5小时
虫号: 695010
注册: 2009-02-02
专业: 药剂学

[求助] 急！！摘要翻译！

包合技术是指一种分子被包藏在另一种分子的空穴结构内形成包合物的技术。药物作为客分子经包合后，溶解度增大，稳定性提高，液体药物可微粉化，可防止挥发性成分的挥发，掩盖药物的不良气味或味道，调节释放速率，提高药物的生物利用度，降低药物的刺激性与毒副作用。
常用的包合材料有环糊精（Cyclodextrin，CYD）、胆酸、淀粉、纤维素、蛋白质、核酸等。目前，在制剂中最常用的是环糊精及其衍生物。制备包合物的方法有饱和水溶液法、超声法、研磨法、冷冻干燥法、喷雾干燥法、溶液搅拌法等。包合物的鉴别方法很多，简单而方便的有显微镜成像法、薄层层析法（TLC）、红外光谱法（IR）、差示热分析法（DSC）等；精细复杂的方法有质谱法（MS）、核磁共振法、X-射线衍射分析法等。

回复此楼

» 猜你喜欢

1楼 2013-06-14 09:14:17

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

cathyLG

木虫 (正式写手)

翻译EPI: 2
应助: 6 (幼儿园)
金币: 3101.3
帖子: 822
在线: 110.6小时
虫号: 1393003
注册: 2011-09-06
专业: 中药学其他科学问题

【答案】应助回帖

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
hanshuang: 金币+100, 翻译EPI+1, ★★★很有帮助, 辛苦了！谢谢。 2013-06-20 13:20:15

Inclusion technique refers to a molecule to be concealed in the hole structure of another molecule to form inclusion complexes technology. As a guest molecule drugs after inclusion, the solubility increases, the stability is improved, the liquid medicine can be micronized to prevent volatilization of volatile components, cover the unpleasant smell or taste, adjust the release rate, to improve bioavailability of the drug, reduce irritation and side effects of drugs.
Common cyclodextrin clathrate material (Cyclodextrin, CYD), cholic acid, starch, cellulose, protein, nucleic acid. Currently, the most commonly used in the formulation is the cyclodextrin and derivatives thereof. The method of preparing a saturated aqueous solution inclusion method, ultrasonic method, grinding, freeze drying, spray drying, the solution was stirred law. Inclusion of identification in many ways, there is a simple and convenient method of microscopy imaging, thin layer chromatography (TLC), infrared spectroscopy (IR), differential scanning calorimetry (DSC), etc.; intricate methods of mass spectrometry (MS), nuclear magnetic resonance, X-ray diffraction method.