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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
hanshuang: 金币+100, 翻译EPI+1, ★★★很有帮助, 辛苦了！谢谢。 2013-06-20 13:20:15
Inclusion technique refers to a molecule to be concealed in the hole structure of another molecule to form inclusion complexes technology. As a guest molecule drugs after inclusion, the solubility increases, the stability is improved, the liquid medicine can be micronized to prevent volatilization of volatile components, cover the unpleasant smell or taste, adjust the release rate, to improve bioavailability of the drug, reduce irritation and side effects of drugs.
Common cyclodextrin clathrate material (Cyclodextrin, CYD), cholic acid, starch, cellulose, protein, nucleic acid. Currently, the most commonly used in the formulation is the cyclodextrin and derivatives thereof. The method of preparing a saturated aqueous solution inclusion method, ultrasonic method, grinding, freeze drying, spray drying, the solution was stirred law. Inclusion of identification in many ways, there is a simple and convenient method of microscopy imaging, thin layer chromatography (TLC), infrared spectroscopy (IR), differential scanning calorimetry (DSC), etc.; intricate methods of mass spectrometry (MS), nuclear magnetic resonance, X-ray diffraction method. |
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