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2Â¥: Originally posted by lxj341401 at 2013-05-23 15:16:28
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C-score (raw cleavage site score)
    The output from the CS networks, which are trained to distinguish signal peptide cleavage sites from everything else.
    Note the position numbering of the cleavage site: the C-score is trained to be high at the position immediately after the cleavage site (the first residue in the mature protein).
S-score (signal peptide score)
    The output from the SP networks, which are trained to distinguish positions within signal peptides from positions in the mature part of the proteins and from proteins without signal peptides.
Y-score (combined cleavage site score)
    A combination (geometric average) of the C-score and the slope of the S-score, resulting in a better cleavage site prediction than the raw C-score alone. This is due to the fact that multiple high-peaking C-scores can be found in one sequence, where only one is the true cleavage site. The Y-score distinguishes between C-score peaks by choosing the one where the slope of the S-score is steep.
4Â¥2013-05-24 11:09:04
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4Â¥: Originally posted by mitocam at 2013-05-24 11:09:04
C-score (raw cleavage site score)
    The output from the CS networks, which are trained to distinguish signal peptide cleavage sites from everything else.
    Note the position numbering of the cl ...

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