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A novel midchain-functional chain transfer agent was synthesized and used as a reversible addition-fragmentation chain transfer polymerization agent to prepare branched poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA). The P(HPMA) contained a thio-reactive group, namely, pyridyldisulfide midchain. The synthesized polymers were fully analyzed by 1H NMR, GPC, and hydrolysis, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). These midfunctionalized polymers were incubated with bovine serum albumin to generate protein-polymer conjugates. This straightforward methodology for the synthesis of branched midfunctionalized polymers for protein conjugation has the potential to enhance the properties of polymer-protein conjugates by improving biomolecule stability and enhancing circulation time. |
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Rio2016
木虫 (小有名气)
- 翻译EPI: 72
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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
wgnydynl: 金币+30, 翻译EPI+1, ★有帮助 2013-04-28 14:00:17
wgnydynl: 金币+30, 翻译EPI+1, ★有帮助 2013-04-28 14:00:17
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A novel midchain-functional chain transfer agent was synthesized and used as a reversible addition-fragmentation chain transfer polymerization agent to prepare branched poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA). 合成了一个新的中链-功能化链转移剂，并将其作为一种逆向加片段型链转移聚合剂来制备枝状PHPMA。 The P(HPMA) contained a thio-reactive group, namely, pyridyldisulfide midchain. PHPMA有一个含硫活性基团，即吡啶基硫化物中链。 The synthesized polymers were fully analyzed by 1H NMR, GPC, and hydrolysis, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). 用1H NMR、GPC和水解对合成的聚合物进行全面分析，证实其有良好的结构（预先设计的分子量、窄的多分散性、高能效）。 These midfunctionalized polymers were incubated with bovine serum albumin to generate protein-polymer conjugates. 将这个中功能化聚合物和牛血清白蛋白孵育，从而产生蛋白质-聚合物缀合体。 This straightforward methodology for the synthesis of branched midfunctionalized polymers for protein conjugation has the potential to enhance the properties of polymer-protein conjugates by improving biomolecule stability and enhancing circulation time. 这个用于合成枝状中功能化聚合物（用于制备蛋白质缀合体）的简单方法，可以通过改善生物分子稳定性和提高循环时间来提高聚合物-蛋白质缀合体的性能。 、、、参考 |
2楼2013-04-22 21:55:20
★ ★ ★ ★ ★
sltmac: 金币-5, 违规存档, 机器翻译，初犯，扣5BB 2013-04-26 10:05:43
sltmac: 金币-5, 违规存档, 机器翻译，初犯，扣5BB 2013-04-26 10:05:43
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3楼2013-04-26 00:07:45
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