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小木虫论坛-学术科研互动平台 » 生物医药区 » 分子生物 » 综合其他 » 蛋白激酶top是什么?
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snake-M

新虫 (初入文坛)

[求助] 蛋白激酶top是什么?

文献中提到这个么一段：药物进入细胞后，和一种受体蛋白-------FKBP12结合成复合物，它可以抑制蛋白激酶TOP的活性，而TOP是细胞循环过程中的重要调节物，使细胞周期G1/S期转换无法实现，从而抑制细胞增殖。
我就查了好多也没有看到有什么蛋白激酶ToP，，，是不是我看错了，，，请问有人了解是怎么回事么？谢谢啦
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1楼 2013-04-08 12:16:25
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pengwenbo

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【答案】应助回帖

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感谢参与，应助指数 +1
amisking: 金币+3, 鼓励发帖应助！ 2013-04-08 18:46:38
应该是拓扑异构酶。

or it should be topoisomerase? However, the function of TOP should be :

Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which
can result from DNA replication, transcription and repair. Common problems such as overwinding (positive
supercoiling), knots and tangles are resolved by topoisomerases by catalysing the breaking of one or two
strands of DNA. Topoisomerase type I enzymes cut just one strand of the DNA double helix, and hence relax
supercoiling of the DNA. Four genes encode Type I topoisomerases, which include nuclear topoisomerase I
(TOP1) and mitochondrial topoisomerase I (TOP1MT). Type I enzymes can also be sub-divided into Types A and B based on their different catalytic mechanism for generating single DNA strand breaks. TOP1 and TOP1MT are both type 1B since they form 3'-phosphotyrosyl bonds. Camptothecin is a natural product inhibitor of TOP1 that has led to the discovery of derivatives that are clinically used anti-cancer drugs. Such inhibitors trap the enzyme in a cleavage complex with DNA. Type II topoisomerases (IIA and IIB) are particular
important for the disentanglement of DNA, which is overcome by generating double stranded DNA breaks.
Dysregulation of type II enzymes can therefore have a potentially significant genotoxic effect. There is a
broad range of topoisomerase II inhibitors that are used clinically as anticancer agents.
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2楼2013-04-08 18:18:17
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