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yin198716

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In addition to a role in tumor angiogenesis, Dll4-Notch signaling also plays a crucial role in T-cell lymphocyte development and differentiation. Gene targeting studies have demonstrated that Notch1 is the essential Notch receptor for T-cell lineage commitment, while Dll4 is the Notch ligand required to induce Notch signaling in thymic immigrant cells and to actively determine T-cell fate. Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells.
Oncology
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hookhans

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Farmer

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Expertise translaiton.
where-there-is-a-will-there-is-a-way.
3楼2013-03-24 10:29:27
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Rio2016

木虫 (小有名气)

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★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
phu_grassman: 金币+2, thanks 2013-03-24 09:20:56
yin198716: 金币+10, 翻译EPI+1, 有帮助 2013-03-24 15:23:47
除了在肿瘤血管生成中发挥作用,Dll4-Notch信号通路也在T淋巴细胞的发育和分化过程中起着关键作用。基因靶向研究表明,Notch1是T细胞系必需的Notch受体,而Dll4是Notch的配体,用来诱导胸腺迁移细胞中的Notch信号通路和决定T细胞的命运。Dll4除在胸腺上皮细胞(TEC)上表达外,也在内皮细胞上表达。


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寥寥数年、将就过活
2楼2013-03-24 08:52:43
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