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| In addition to a role in tumor angiogenesis, Dll4-Notch signaling also plays a crucial role in T-cell lymphocyte development and differentiation. Gene targeting studies have demonstrated that Notch1 is the essential Notch receptor for T-cell lineage commitment, while Dll4 is the Notch ligand required to induce Notch signaling in thymic immigrant cells and to actively determine T-cell fate. Dll4 is constitutively expressed on the thymic epithelial cells (TEC) as well as on endothelial cells. |
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Rio2016
ľ³æ (СÓÐÃûÆø)
- ·ÒëEPI: 72
- Ó¦Öú: 28 (СѧÉú)
- ¹ó±ö: 0.013
- ½ð±Ò: 3301.7
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- Ìû×Ó: 300
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phu_grassman: ½ð±Ò+2, thanks 2013-03-24 09:20:56
yin198716: ½ð±Ò+10, ·ÒëEPI+1, ¡ïÓаïÖú 2013-03-24 15:23:47
phu_grassman: ½ð±Ò+2, thanks 2013-03-24 09:20:56
yin198716: ½ð±Ò+10, ·ÒëEPI+1, ¡ïÓаïÖú 2013-03-24 15:23:47
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2Â¥2013-03-24 08:52:43
hookhans
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Farmer
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- ³æºÅ: 2260260
- ×¢²á: 2013-01-25
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3Â¥2013-03-24 10:29:27













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