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chenniuniu: 金币+35, 翻译EPI+1 2012-08-29 09:43:28
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In recent years, avian infectious bronchitis (IB) has been prevalent, and IB attenuated vaccine is indispensable to prevent the disease. However, IB virus tends to mutate, with its mutant strains founded continually, so the disease cannot be well controlled by the existing vaccines. Therefore, it is an irresistible trend to attenuate the virus from local isolated strain. This paper mainly discusses the method for constructing IB attenuated vaccine. IB attenuated vaccine is acquired mainly by attenuating virus in a natural way or an artificial way. Modern molecular biological method and reverse genetics technique can be used to produce the attenuated vaccine that is safer, has broader spectrum, and shows higher effectiveness, so as to overcome the disadvantages of traditional attenuated vaccine. |
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