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·ÖÎö¶àëÄÓëMHCÏ໥×÷ÓõÄÈí¼þ
SYFPEITHI: http://www.syfpeithi.de/
database for MHC ligands and peptide motifs.
The first version of the major histocompatibility complex (MHC) databank SYFPEITHI: database for MHC ligands and peptide motifs, is now available to the general public. It contains a collection of MHC class I and class II ligands and peptide motifs of humans and other species, such as apes, cattle, chicken, and mouse, for example, and is continuously updated. All motifs currently available are accessible as individual entries. Searches for MHC alleles, MHC motifs, natural ligands, T-cell epitopes, source proteins/organisms and references are possible. Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only.
MHC ÅäÌåºÍ¶àëÄ»ùÐòµÄÊý¾Ý¿â
Ö÷Òª×éÖ¯ÏàÈÝÐÔ¸´ºÏÌ壨MHC£©µÄÊý¾Ý¿âµÄµÚÒ»¸ö°æ±¾¡£SYFPEITHI£ºÏÖÓÐMHC ÅäÌåºÍ¶àëÄ»ùÐòµÄÊý¾Ý¿âÌṩ¸ø¹ã´ó¹«ÖÚ¡£Ëü°üº¬ÈËÀàºÍÆäËûÎïÖÖ£¬ÈçÔ³£¬Å££¬¼¦ºÍÊóµÄMHC IÀàºÍIIÀàÅäÌåºÍ±í룬²¢²»¶Ï¸üС£Ä¿Ç°ËùÓеĻùÐò¶¼¿ÉÒÔ·ÃÎÊ¡£ËÑË÷MHCµÈλ»ùÒò£¬MHC»ùÐò£¬×ÔÈ»µÄÅäÌ壬Tϸ°û±íλ£¬Ô´µ°°×ÖÊ»òÕß΢ÉúÎïÒÔ¼°²Î¿¼ÎÄÏ׵ȶ¼¿ÉÒÔ¡£²¢ÇÒ¿ÉÒÔºÍEMBLºËPubMedÊý¾Ý¿âÏàÁ´½Ó¡£´ËÍ⣬¿ÉÒÔ½øÐÐÕë¶ÔMHCµÈλ»ùÒòµÄ²úÎïµÄÅäÌåÔ¤²â¡£Êý¾Ý¿âµÄÄÚÈݽöÏÞÓÚÒѾ­·¢±íµÄÊý¾Ý¡£
http://www.imtech.res.in/raghava/mhcbn/
http://epitope.liai.org:8080/too ... input?matrixClass=I,II
http://www.imtech.res.in/raghava/propred1/
http://www-bimas.cit.nih.gov/molbio/hla_bind/
http://www.mpiib-berlin.mpg.de/MAPPP/expertquery.html
http://margalit.huji.ac.il/
http://www.epipredict.de/index.html
http://www.epipredict.de/index.html
http://www.ebi.ac.uk/imgt/
http://bio.dfci.harvard.edu/Tools/rankpep.html
http://www.imtech.res.in/raghava/mhcbench/
http://www.imtech.res.in/raghava/nhlapred/
http://www-bs.informatik.uni-tuebingen.de/Services/SVMHC
http://www.imtech.res.in/raghava/propred/
http://www.cbs.dtu.dk/services/NetMHC/
http://www.cbs.dtu.dk/services/NetMHCII/
http://www.cbs.dtu.dk/services/NetMHCpan/
http://zlab.bu.edu/SMM/
http://iclab.life.nctu.edu.tw/POPI/
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gl19860312

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Antigenic peptides:
Prediction of Antigenic Determinants - prediction of peptides likely to elicit an antibody response
http://bio.dfci.harvard.edu/Tools/antigenic.pl
ANTIGENIC (EMBOSS package) - prediction of peptides likely to elicit an antibody response
http://emboss.ch.embnet.org/Pise/antigenic.html
BepiPred - prediction of linear B-cell epitopes
http://www.cbs.dtu.dk/services/BepiPred/
DiscoTope - prediction of discontinuous B-cell epitopes
http://www.cbs.dtu.dk/services/DiscoTope/
CTL epitopes:
CTLPred - prediction of CTL epitopes
http://www.imtech.res.in/raghava/ctlpred/
EpiJen - prediction of T cell epitopes
http://www.jenner.ac.uk/EpiJen/
NetCTL - prediction of CTL epitopes
http://www.cbs.dtu.dk/services/NetCTL/
Tumor antigens:
VaxiJen - prediction of tumor antigens
http://www.jenner.ac.uk/VaxiJen/
TEPITOPE http://www.vaccinome.com/pages/597444/
Vaccinome's TEPITOPE is a software package for the prediction of promiscuous HLA-class II binding peptides and human T-cell epitopes. Quantitative matrix-based HLA-DR motifs covering a large part of the human HLA class II ligand specificity were incorporated into this first version of TEPITOPE. The compact design of TEPITOPE's user interface allows the identification of promiscuous HLA class II ligands in any protein sequence simply by pressing a few buttons!
VaccinomeµÄTEPITOPEÊÇ·ºÐÔµÄÔ¤²âHLA- IIÀà·Ö×Ó½áºÏëĺÍÈËÀàTϸ°û±íλµÄÈí¼þ°ü¡£¸²¸ÇÁ˴󲿷ÖÈËÀàHLA - IIÀàÅäÌåÌØÒìÐÔµÄÒÔÁ¿»¯¾ØÕóΪ»ù´¡µÄHLA - DRµÄ»ùÐò±»ÄÉÈëÕâ¸öTEPITOPEµÄµÚÒ»¸ö°æ±¾¡£ÔÚ½ô´ÕÉè¼ÆµÄTEPITOPEµÄÓû§½çÃæ£¬Ö»Ðè°´¼¸¸ö°´Å¥£¬Èκε°°×ÖʵÄÐòÁеķºÐÔµÄHLA - IIÀàÅäÌå¼´¿É¼ø¶¨£¡
MHCPred http://www.jenner.ac.uk/MHCPred/
A server for quantitative prediction of peptide-MHC binding
Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at large, we have implemented, as a server on the World Wide Web, a partial least squares-based multivariate statistical approach to the quantitative prediction of peptide binding to major histocom- patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701). MHCPred is available from the URL: http://www.jenner.ac.uk/MHCPred.
Ò»ÖÖ¶¨Á¿Ô¤²â¶àëĺÍMHC½áºÏµÄ·þÎñÆ÷
¾«×¼µÄTϸ°û±íλԤ²âÊǼÆËãÒßÃçѧµÄÖ÷ҪĿ±ê¡£Îª·þÎñÓÚ¹ã´óÒßÃçѧºÍÃâÒßѧȺÌ壬×÷ΪÍòÎ¬ÍøµÄÒ»¸ö·þÎñÕߣ¬ÎÒÃÇʵʩÁËÒ»¸öÖÁÉÙ²¿·Ö»ùÓÚ¶þ³Ë¶àÔª·½³ÌµÄ¶¨Á¿Ô¤²â½áºÏÓÚMHCµÄ¶àëĵķ½·¨£¬ÊÇ»ñµÃÐÔÃâÒßÖп¹Ô­µÝ³Ê;¾¶µÄÒ»¸ö¹Ø¼üµã¡£MHCPredʵÏÖIÀà·Ö×ÓµÈλ»ùÒò¼áʵµÄͳ¼ÆÄ£ÐÍ£¨(HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501)ºÍ¢òÀàµÈλ»ùÒò(HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701)¡£MHCPredÍøÖ·£ºhttp://www.jenner.ac.uk/MHCPred¡£

http://wehih.wehi.edu.au/mhcpep/
A database of MHC binding peptides
MHCPEP is a database comprising over 13000 peptide sequences known to bind MHC molecules. Entries were compiled from published reports as well as from direct submissions of experimental data. Each entry contains the peptide sequence, its MHC specificity and, when available, experimental method, observed activity, binding affinity, source protein, anchor positions, and publication references.

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MHCPEPÊÇÒ»¸öÊý¾Ý¿â£¬°üÀ¨³¬¹ý13000ÒÑÖª½áºÏMHC·Ö×ӵĶàëÄÐòÁС£ÓÉ·¢±íµÄ±¨¸æÒÔ¼°´ÓʵÑéÊý¾ÝÖ±½ÓÌá½»¡£Ìá½»µÄÿ¸öÌõÄ¿°üº¬¶àëÄÐòÁУ¬ÆäMHCµÄÌØÊâÐÔ£¬ÊµÑé·½·¨£¬¹Û²ìµ½µÄ»îÐÔ£¬½áºÏµÄÇ׺ÍÁ¦£¬Ô´µ°°×ÖÊ£¬Ãª¶§Î»Ö㬺ͳö°æÎï²Î¿¼¡£
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