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Several solvent water molecules, especially O10, O11 and O12 have very large thermal ellipsoids. The authors may wish to consider a multi-site disorder model, or to make some comment on possible positional disorder of these atoms. It also seems slightly unusual that the hydrogen atom positions for these water molecules have been determined from diffraction measurements rather than calculated given the large ellipsoids of the oxygen. Further investigation of the solvent water positions may also help to address the CheckCIF concerns over large reported positive and negative residual density.It is, however, appreciated that it can be challenging to adequately model disordered solvent and the best course of action may be just to add a comment on potential disorder and relatively large residual density in this case. ¿´²»Ì«¶®£¬Éó¸åÈËÊDz»ÊÇÔÚ¹í·åÖÐÕÒÇ⣿ÊDz»ÊÇ»¹Òª°ÑO·Ö³ÉÁ½¸ö£¿ OÊÇÈܼÁH2OÖеİ¡£¬ºÜÄÑÔÚ¹í·åÖÐÕÒ×¼°¡£¿£¡ Çó¸ßÊÖÖ¸µã |
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