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Sodium triethylborohydride  (840 ¦ÌL of a 1 M solution in THF, 0.843 mmol, 10 equ iv) was added dropwise to a room  temperature solution of digoxin (65.8 mg, 0.0843 mmol, 1.0  equiv) in THF (16.9 mL, 5  mM). After 10 min, the reaction was quenched with the slow addition of methanol (5  mL), stirred for 15 min, and concentrated in vacuo to afford an inseparable mixture of  saturated diol (Dig(dhd)) and alkene diol (20,22 -alkene) (~3:1 of satur ated:alkene) as a white solid.  R f  = 0.15 (9:1 ethyl acetate/methanol).  The crude material was used without  purification.  
To the above mixture of compounds in methanol (4.2 mL, 20 mM) was added  10 wt% palladium on carbon (9.0 mg, 0.0084 mmol, 0.1 equiv). The reaction atmosphere  was sparged with hydrogen and the contents were stirred under a balloon of hydrogen for  16 h, at which point the reaction was filt ered through Celite and concentrated in vacuo.  The crude material was dry-loaded onto Celite and purified by flash chromatography on  silica gel (19:1 ¡ú 9:1  ¡ú 85:15 dichloromethane/methanol) to afford Dig(dhd) (63.7 mg,  0.0809 mmol, 96% yield over two steps ) as a white solid. Dig(dhd) was obtained as a  ~1.5:1 mixture of diastereomers that were not separated.
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