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2Ôµ×ͶÁËһƪÎÄÕµ½JBC£¬Éó¸åºÜ¿ì£¬°ë¸öÔ¾͸ø³öÉó¸å½á¹ûÁË£¬¿ÉÊÇÁîÈ˺ܾÀ½á£¬±à¼²¢Ã»Óоܵô£¬¶øÊÇÏ£Íû¸ÄºóÖØÍ¶£¨declined and resubmitted£©¡£ÎÒ×Ðϸ¿´ÁËÁ½¸öÉó¸åÈ˵ÄÒâ¼û£¬µÚ¶þ¸öÉó¸åÈ˵ÄÒâ¼û±È½Ï¾ßÌ壬¶øÇÒ´ó¶àÊÇд×÷·½ÃæµÄ£¬»¹±È½ÏÄܹ»Õë¶ÔÐÔµØÐ޸컵«µÚÒ»¸öÉó¸åÈ˾ÍÖ»ÓÐÒ»¾ä»°The study while interesting is descriptive in nature.ÈÃÈ˺ÜÊÇ×¥¿ñ ¡£ÓÉÓÚ±à¼ÒѸæÖªÔÙͶʱÐèÒªÔÚcover letterÖÐÏêϸ˵Ã÷Õë¶ÔÉó¸åÈËÌá³öµÄÒâ¼ûµÄÐÞ¸ÄÇé¿ö£¬ÏÖÔÚ²»ÖªµÀ¸ÃÈçºÎ¶ÔÕâÑùµÄÉó¸åÒâ¼û×ö³ö»Ø¸´£¬¿ÒÇë¸ßÈ˸ø³öÒâ¼û¡£ÏÂÃæ¸½ÉÏÉó¸åÐÅÔÎÄ£º Your manuscript has been reviewed by the Editorial Board. Unfortunately, the decision was made to decline the manuscript in its current form. One reviewer indicates that the study is too descriptive and the other finds numerous items that need attention. If you can address the issues raised, I would be willing to consider a revised paper. Note that no guarantee of acceptance of the revised manuscript is implied. Reviewer 1 COMMENTS FOR THE AUTHOR: The study while interesting is descriptive in nature. Reviewer 2 COMMENTS FOR THE AUTHOR: Manuscript No: JBC/2012/356428 Comments to the authors: The manuscript reports that YCP selectively promotes the activation of B cells through Toll-like receptor 2 and Toll-like receptor 4. The authors presented experimental evidence to show that YCP binds to TLR2 and TLR4 of B cell, activates a serial events of signaling pathways including p38, ERK, JNK, and NF-¦ÊB , which eventually leads to the activation of B cell as indicated by proliferation and IgM production. The experiments are designed reasonable and well down, the findings are significant. The manuscript needs revision: 1. It seems to me that the ¡°EXPERIMENTAL PROCEDURES¡± part is too wordy. 2. I recommend authors to re-write the ELISA-paragraph. 3. In the figure 2-A, each panel should also includes the same field panel with normal light observation to show all the cells in the field. 4. Let the editor to decide if the figure 6 is necessary, or in other words, if there is enough information to construct the signaling pathway? 5. English language should be checked carefully for accurate and unambiguous expressions. |
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