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1.Ë®ÈÜÐÔÁ¿×ÓµãÓÉÓÚÆä±¾ÉíÁ£¾¶½ÏСÊDz»ÊÇ»áÖ±½Ó½øÈëϸ°û£¿»¹ÓÐûÓÐÆäËûÔÒòʹµÃÁ¿×Óµã½øÈëϸ°û°¡£¿
Comment: Depending the surface ligands and cell lines, QDs can possibly enter the cells via simple endocytosis. Othe possible approaches to deliver QDs into the cells include the aid of cell penetrating peptides, targeting ligands, pulsed injection and so on.
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Comment: Size is only one of many parameters affecting the cellular uptake of nanoparticles. In some cases, nanoparticles larger than 100 nm can also be easily internalized by macrophage. Conjugation of QDs with antibody can also possibly enter the cells even the size becomes larger.
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Comment: Usually, QDs with neutral charge have very low uptake efficiency. For example, QDs functionalized with PEG is well known to minimize non-specific cellular uptake.
Recommend a nice review to you:
Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies, Nano Today 2011, 6, 176. http://217.219.202.60/documents/ ... ar+transport+of.pdf
Good luck! |
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