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On a historical time scale, the identification of the structures and confirmation of the hormone status of some of these putative hormones has come rel- atiyely recently tnd in rather small amounts. Cur- rently, only secretin, gastrin, and cholecystokinin- pancreozymin fit the four criteria which have been established to define a substance as a GI hormone: 1) physiological demonstration that a stimulus ap- plied to one structure results in modification of the activity of another structure or of another part of the same structure; 2) physiological demonstration that the effect on the target structure persists after all nervous connections between the site of stimulus and the target structure are removed; 3) evidence that isolation from the stimulated site ofa substance produces the observed effect on the target tissue; and 4) chemical identification of the substance and proof of its structure by synthesis |
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°®ÓëÓêÏÂ(½ð±Ò+1): 2011-12-23 08:49:55
Ììʹ@°®ÃÀÀö(½ð±Ò+8, ·ÒëEPI+1): 2011-12-23 09:11:12
°®ÓëÓêÏÂ(½ð±Ò+1): 2011-12-23 08:49:55
Ììʹ@°®ÃÀÀö(½ð±Ò+8, ·ÒëEPI+1): 2011-12-23 09:11:12
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