24小时热门版块排行榜    

查看: 1952  |  回复: 4
当前只显示满足指定条件的回帖,点击这里查看本话题的所有回帖

doudou100988

银虫 (初入文坛)

[求助] 急切求助,论文一审结果出来了,这样的意见怎么回复呢~~~?

Reviewing: 1
Comments to the Author
This manuscript described method validation for the analysis of salbutamol in human plasma and urine. The article is well written and validation is comprehensive. The manuscript can be published with the following two minor comments.
1. The selection of the internal standard should be more carefully considered. The published method is intended to be used by other scientists. Use of a very common OTC drug acetaminophen may limit the application of this method for broad usage. To reviewer’s knowledge, stable labeled salbutamol is commercially available. For a LC-MS/MS bioanalytical method, use of stable-labeled internal standard is preferred.
2. The plasma sample volume (1 ml) is relatively large for a typical LC-MS/MS method. The use of large sample volume and large volume for extraction also prevent using of automated sample extraction in a 96-well format and therefore reduces the sample throughput. Has a smaller volume been tested?


Reviewing: 2
Comments to the Author
A good method for the determination of salbutamol except for the choice of internal standard. The paper is well written and the results clearly presented and discussed.

[ Last edited by doudou100988 on 2011-11-7 at 10:58 ]
回复此楼

» 猜你喜欢

» 本主题相关价值贴推荐,对您同样有帮助:

已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

duyumeng1989

新虫 (初入文坛)

引用回帖:
3572014楼: Originally posted by doudou100988 at 2011-11-07 11:07:17:
第一个专家提出对乙酰氨基酚是普通非处方药,不太稳定,需要怎么回复呢,要补充的稳定性数据么,还有选用非处方药做内标有什么不好么?

请问对乙酰氨基酚不太稳定吗?容易水解吗?
5楼2012-05-24 09:32:08
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
查看全部 5 个回答

wht3198

木虫 (著名写手)

【答案】应助回帖

doudou100988(金币+5): 谢谢了,那请问专家提出对乙酰氨基酚不稳定,应该怎么回复呢,给出稳定性的数据么 2011-11-07 11:05:04
呵呵 小修啊 按照审稿改改 应该没有问题
2楼2011-11-07 10:59:56
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖

doudou100988

银虫 (初入文坛)

第一个专家提出对乙酰氨基酚是普通非处方药,不太稳定,需要怎么回复呢,要补充的稳定性数据么,还有选用非处方药做内标有什么不好么?
3楼2011-11-07 11:07:17
已阅   回复此楼   关注TA 给TA发消息 送TA红花 TA的回帖
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[基金申请] 能否申诉? +4 echo8914667 2026-08-30 5/250 2026-08-30 21:11 by echo8914667
[基金申请] 29号明天会评吗 +3 笨笨唐 2026-08-28 3/150 2026-08-30 09:29 by cww8181
[基金申请] 我就是申请一个面上项目而已,这评审意见是按照杰青的条件评的吧? +6 gouxfjh 2026-08-28 11/550 2026-08-30 07:57 by gouxfjh
[基金申请] 国自然面上复盘~欢迎讨论 (金币+15) +15 晴天加油 2026-08-26 16/800 2026-08-29 18:28 by symmetry
[基金申请] 基金不中,共勉 +11 eulota 2026-08-26 11/550 2026-08-28 14:22 by 火星超人xi
[基金申请] 基金系统什么内容也没有 30+4 winsaint 2026-08-27 9/450 2026-08-28 11:06 by maolC
[基金申请] 怎么看青基中了没有啊 +5 叶九微 2026-08-26 5/250 2026-08-27 10:35 by l_zh2008
[文学芳草园] 梦想 +3 myrtle 2026-08-26 3/150 2026-08-27 10:01 by angelyueyi
[基金申请] 为什么 国际(地区)合作与交流项目 没有放榜? 10+3 majunge000 2026-08-26 11/550 2026-08-27 08:42 by 北京莱茵编辑
[基金申请] 我不理解! +15 Edward_pc 2026-08-26 23/1150 2026-08-26 20:34 by zzuzxg
[基金申请] 2026年8月25日国自然放榜前突然收到列入评审专家邮件,有关系吗? +25 木水思豆 2026-08-25 28/1400 2026-08-26 14:53 by draco1987
[基金申请] 能否退出参与的面上项目解除限项 +23 koalala 2026-08-24 26/1300 2026-08-26 14:29 by 宝贝虫子
[基金申请] 为什么国自然不能直接公布 +4 bjdxyxy 2026-08-26 4/200 2026-08-26 13:12 by qingmu1201
[基金申请] 国际合作可查了,中了面上 (EPI+1)(金币+50) +18 Ldrop2023 2026-08-26 18/900 2026-08-26 11:15 by cmrandy
[基金申请] 系统进不去 +4 yanglien 2026-08-26 5/250 2026-08-26 11:10 by wenfengw83
[基金申请] 国合可查了 +3 paperzjh 2026-08-26 3/150 2026-08-26 10:41 by LemmonTr
[基金申请] 今天务委会开完了,明天出结果吗 +19 angus9576 2026-08-25 23/1150 2026-08-26 10:03 by zp519
[基金申请] 国合现在查不到了吗? +10 chengyan1220 2026-08-24 20/1000 2026-08-26 08:57 by peasantsprig
[基金申请] 在坚冰还盖着北海的时候,我看到了怒放的梅花。 (金币+10) +6 ziyangfang 2026-08-25 9/450 2026-08-25 20:26 by huagongfeihu
[基金申请] 如果此刻你正在为国基感到焦虑,不妨来听听这首《基金之外》 +8 scalable 2026-08-24 8/400 2026-08-25 12:52 by jnhyjjm
信息提示
请填处理意见