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Practical Monitoring and Coagulation Laboratory Insights Coagulation Laboratory Considerations Coagulation testing is used in a variety of settings: screen for factor deficiencies (PT/ aPTT), monitoring drug efficacy (PT/aPTT), and exclude disease states (D-dimer). Variables affecting coagulation testing include preanalytical (e.g., timing of blood collection, processing, timing, and suitability) and analytical (e.g., instrument and reagent systems), which may impact the accuracy of the reported result. These variables can lead to notable differences in reported results between laboratories and should be taken into consideration when using observations in the literature or from an outside hospital, and in developing or adjusting the anticoagulant management plan. Lastly, the laboratory evaluation/testing should be interpreted as a surrogate marker of the hemostasis process, as these data may not be an absolute reflection of in vivo coagulation or hard outcomes. |
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