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【答案】应助回帖
边关2008(金币+5, 翻译EPI+1): 2011-08-29 15:42:25
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In addition, they tend to be potent cytotoxins by mechanisms independent of a bioreductive activation (i.e., by hindering the movement of polymerases or interfering with the action of topoisomerases I or II along DNA), which decreases hypoxic selectivity.此外，它们倾向于通过不依赖于生物还原激活的机制作为潜在的细胞毒素，生物还原激活降低缺氧选择性。Another limitation associated with strong DNA-intercalators is their aerobic radioprotection which has been observed both in vitro and in vivo. 另一个与强DNA嵌入剂有关的限制是在体内和体外实验中都观察到的它们的需氧放射防护。 |
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