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Notably,neither of the naturally occurring alkaloids tested had activity
at any of the opioid receptors. Although Sig-R binding mediates the activity of some nonnarcotic antitussive agents, such as dextrophan(41), the lack of Sig-R binding in neostenine indicates that the source of this antitussive activity of this compound is still unknown. Target identification studies, along with the independent validation of the in vivo literature results, are called for but beyond the scope of the present paper.

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ÑÌÔÆÌýÓê(½ð±Ò+8, ·­ÒëEPI+1): лл 2011-07-19 12:26:24
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Notably,neither of the naturally occurring alkaloids tested had activity at any of the opioid receptors.ÖµµÃ×¢ÒâµÄÊÇ£¬ÊÔÑé¹ýµÄÌìÈ»´æÔÚÉúÎï¼î¾ùÎÞ°¢Æ¬ÊÜÌå»îÐÔ¡£ Although Sig-R binding mediates the activity of some nonnarcotic antitussive agents, such as dextrophan(41), the lack of Sig-R binding in neostenine indicates that the source of this antitussive activity of this compound is still unknown. ¾¡¹ÜSig-R ½áºÏ½éµ¼ÁËijЩ·ÇÂé×íÐÔÕò¿È¼ÁÈçÓÒÐýÂð·ÈµÄ»îÐÔ£¬µ«ÐÂË¹ÌæÄþ¼îȱ·¦ÓëSig-RµÄ½áºÏÌáʾ´Ë»¯ºÏÎïÕò¿È»îÐÔÔ´×Ժδ¦Éв»µÃ¶øÖª¡£Target identification studies, along with the independent validation of the in vivo literature results, are called for but beyond the scope of the present paper.°Ð±êʶ±ðÒÔ¼°¶ÔÌåÄÚÑо¿ÎÄÏ×½á¹ûµÄ¶ÀÁ¢ÑéÖ¤¶¼ÊǼ±ÐèµÄ¹¤×÷£¬µ«±¾ÎÄδÓèÉæ¼°¡£
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