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ÑÌÔÆÌýÓê(½ð±Ò+8, ·ÒëEPI+1): лл 2011-07-19 12:26:24
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| Notably,neither of the naturally occurring alkaloids tested had activity at any of the opioid receptors.ÖµµÃ×¢ÒâµÄÊÇ£¬ÊÔÑé¹ýµÄÌìÈ»´æÔÚÉúÎï¼î¾ùÎÞ°¢Æ¬ÊÜÌå»îÐÔ¡£ Although Sig-R binding mediates the activity of some nonnarcotic antitussive agents, such as dextrophan(41), the lack of Sig-R binding in neostenine indicates that the source of this antitussive activity of this compound is still unknown. ¾¡¹ÜSig-R ½áºÏ½éµ¼ÁËijЩ·ÇÂé×íÐÔÕò¿È¼ÁÈçÓÒÐýÂð·ÈµÄ»îÐÔ£¬µ«ÐÂË¹ÌæÄþ¼îȱ·¦ÓëSig-RµÄ½áºÏÌáʾ´Ë»¯ºÏÎïÕò¿È»îÐÔÔ´×Ժδ¦Éв»µÃ¶øÖª¡£Target identification studies, along with the independent validation of the in vivo literature results, are called for but beyond the scope of the present paper.°Ð±êʶ±ðÒÔ¼°¶ÔÌåÄÚÑо¿ÎÄÏ×½á¹ûµÄ¶ÀÁ¢ÑéÖ¤¶¼ÊǼ±ÐèµÄ¹¤×÷£¬µ«±¾ÎÄδÓèÉæ¼°¡£ |
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