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【答案】应助回帖
烟云听雨(金币+5, 翻译EPI+1): 谢谢！ 2011-07-13 12:36:40
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We therefore did not feel constrained in the range of chemical manipulations we could explore, and in many cases the final compounds bear little resemblance to any known Stemona alkaloid. 因而我们广泛的探索了多种化学手段，在许多情况下，最终得到的化合物与任何已知的百部生物碱几乎没有相似之处。Herein, we report the initial evaluation of these compounds against a panel of G protein-coupled receptor (GPCR) targets relevant to central nervous system function and how those results have inspired additional library design, ultimately resulting in a series of highly potent Sig-R ligands.在此，我们报道这些化合物针对一组与中枢神经系统功能相关的G蛋白偶联受体靶标的初始评估，以及如何以这些结果指导更多的文库设计来发现一系列的高效Sig-R配体。 |
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