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We therefore did not feel constrained in the range of chemical
manipulations we could explore, and in many cases the final compounds
bear little resemblance to any known Stemona alkaloid.
Herein, we report the initial evaluation of these compounds
against a panel of G protein-coupled receptor (GPCR) targets
relevant to central nervous system function and how those results
have inspired additional library design, ultimately resulting in a
series of highly potent Sig-R ligands.

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ÑÌÔÆÌýÓê(½ð±Ò+5, ·­ÒëEPI+1): лл£¡ 2011-07-13 12:36:40
We therefore did not feel constrained in the range of chemical manipulations we could explore, and in many cases the final compounds bear little resemblance to any known Stemona alkaloid. Òò¶øÎÒÃǹ㷺µÄ̽Ë÷Á˶àÖÖ»¯Ñ§ÊֶΣ¬ÔÚÐí¶àÇé¿öÏ£¬×îÖյõ½µÄ»¯ºÏÎïÓëÈκÎÒÑÖªµÄ°Ù²¿ÉúÎï¼î¼¸ºõûÓÐÏàËÆÖ®´¦¡£Herein, we report the initial evaluation of these compounds against a panel of G protein-coupled receptor (GPCR) targets relevant to central nervous system function and how those results have inspired additional library design, ultimately resulting in a series of highly potent Sig-R ligands.ÔÚ´Ë£¬ÎÒÃDZ¨µÀÕâЩ»¯ºÏÎïÕë¶ÔÒ»×éÓëÖÐÊàÉñ¾­ÏµÍ³¹¦ÄÜÏà¹ØµÄGµ°°×żÁªÊÜÌå°Ð±êµÄ³õʼÆÀ¹À£¬ÒÔ¼°ÈçºÎÒÔÕâЩ½á¹ûÖ¸µ¼¸ü¶àµÄÎÄ¿âÉè¼ÆÀ´·¢ÏÖһϵÁеĸßЧSig-RÅäÌå¡£
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