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烟云听雨铁杆木虫 (正式写手)
金虫
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[求助]
求助有机化学翻译一小段
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We therefore did not feel constrained in the range of chemical manipulations we could explore, and in many cases the final compounds bear little resemblance to any known Stemona alkaloid. Herein, we report the initial evaluation of these compounds against a panel of G protein-coupled receptor (GPCR) targets relevant to central nervous system function and how those results have inspired additional library design, ultimately resulting in a series of highly potent Sig-R ligands. |
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8814402
至尊木虫 (职业作家)
- 翻译EPI: 509
- 应助: 18 (小学生)
- 贵宾: 0.381
- 金币: 12921.1
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- 帖子: 4185
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- 虫号: 1184404
- 注册: 2011-01-06
- 专业: 药物学其他科学问题
【答案】应助回帖
烟云听雨(金币+5, 翻译EPI+1): 谢谢！ 2011-07-13 12:36:40
| We therefore did not feel constrained in the range of chemical manipulations we could explore, and in many cases the final compounds bear little resemblance to any known Stemona alkaloid. 因而我们广泛的探索了多种化学手段，在许多情况下，最终得到的化合物与任何已知的百部生物碱几乎没有相似之处。Herein, we report the initial evaluation of these compounds against a panel of G protein-coupled receptor (GPCR) targets relevant to central nervous system function and how those results have inspired additional library design, ultimately resulting in a series of highly potent Sig-R ligands.在此，我们报道这些化合物针对一组与中枢神经系统功能相关的G蛋白偶联受体靶标的初始评估，以及如何以这些结果指导更多的文库设计来发现一系列的高效Sig-R配体。 |
2楼2011-07-13 10:32:38
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