| 查看: 702 | 回复: 3 | ||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
ky888银虫 (正式写手)
|
[求助]
帮忙翻译下吧 不懂啊
|
|
|
组合化学库的应用Library applications The electrochemical behaviour of an indole library of compounds, including several tryptophan and tryptamine derivatives previously demonstrated to be active against reactive oxygen species (ROS), has been investigated. A voltammetry study has been undertaken and the oxidation potential was correlated to the scavenging activity reported for these indoles.9 Tripeptides such as RGD and NGR are showing promising results for targeted drug delivery and in vivo imaging. An on resin Huisgen’s 1,3-dipolar cycloaddition has been used to synthesise new cyclic RGD and NGR peptide analogues and preliminary binding assays of these new analogues by fluorescence polarisation indicated specific binding to purified CD13 (Aminopeptidase N) and cell lysates from MCF-7 and SKOV-3 cancer cell lines.10 A novel series of quinolinone-based adenosine A2B receptor antagonists has been identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogues highlighted essential structural features of the initial hit, and subsequent optimisation resulted in an A2B antagonist which exhibited potent activity in cAMP accumulation and IL-8 release assays.11 Screening of a pteridine-based compound library led to the identification of compounds exhibiting immunosuppressive as well as anti-inflammatory activity. Optimisation afforded a series of 2-amino- 4-N-piperazinyl-6-(3,4-dimethoxyphenyl)pteridine analogues, the most potent of which displayed low nM IC50 values in the Mixed Lymphocyte Reaction (MLR) assay.12 |
回复此楼» 猜你喜欢
急需调剂
已经有8人回复
-
申博/考博
已经有4人回复
-
化工学硕294分，求导师收留
已经有37人回复
-
求调剂
已经有11人回复
-
260求调剂
已经有4人回复
-
一志愿华中农业071010，320求调剂
已经有19人回复
-
304求调剂
已经有7人回复
-
求博导｜生物质基多孔碳/超级电容方向，已有相关成果，寻能源材料/碳材料方向老师
已经有3人回复
-
二苯甲酮酸类衍生物
已经有6人回复
-
接受任何调剂
已经有4人回复
hanklu
金虫 (正式写手)
- 翻译EPI: 3
- 应助: 0 (幼儿园)
- 金币: 1363.2
- 帖子: 502
- 在线: 33.7小时
- 虫号: 244288
- 注册: 2006-04-16
- 专业: 中药制剂
4楼2011-07-04 00:08:47
ky888
银虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 194.6
- 散金: 6
- 帖子: 398
- 在线: 45.5小时
- 虫号: 649359
- 注册: 2008-11-08
- 性别: GG
- 专业: 有机合成
2楼2011-07-02 10:17:49
ky888
银虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 194.6
- 散金: 6
- 帖子: 398
- 在线: 45.5小时
- 虫号: 649359
- 注册: 2008-11-08
- 性别: GG
- 专业: 有机合成
3楼2011-07-02 11:39:52
