| 查看: 708 | 回复: 3 | ||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
ky888银虫 (正式写手)
|
[求助]
帮忙翻译下吧 不懂啊
|
|
|
组合化学库的应用Library applications The electrochemical behaviour of an indole library of compounds, including several tryptophan and tryptamine derivatives previously demonstrated to be active against reactive oxygen species (ROS), has been investigated. A voltammetry study has been undertaken and the oxidation potential was correlated to the scavenging activity reported for these indoles.9 Tripeptides such as RGD and NGR are showing promising results for targeted drug delivery and in vivo imaging. An on resin Huisgen’s 1,3-dipolar cycloaddition has been used to synthesise new cyclic RGD and NGR peptide analogues and preliminary binding assays of these new analogues by fluorescence polarisation indicated specific binding to purified CD13 (Aminopeptidase N) and cell lysates from MCF-7 and SKOV-3 cancer cell lines.10 A novel series of quinolinone-based adenosine A2B receptor antagonists has been identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogues highlighted essential structural features of the initial hit, and subsequent optimisation resulted in an A2B antagonist which exhibited potent activity in cAMP accumulation and IL-8 release assays.11 Screening of a pteridine-based compound library led to the identification of compounds exhibiting immunosuppressive as well as anti-inflammatory activity. Optimisation afforded a series of 2-amino- 4-N-piperazinyl-6-(3,4-dimethoxyphenyl)pteridine analogues, the most potent of which displayed low nM IC50 values in the Mixed Lymphocyte Reaction (MLR) assay.12 |
回复此楼» 猜你喜欢
国自然面上和省基金B类撒花
已经有16人回复
-
有没有学校收留
已经有3人回复
-
312求调剂
已经有3人回复
-
华师大读博
已经有5人回复
-
又一批高校组建人工智能学院 师资行吗 不是骗人吗
已经有5人回复
-
急需审稿人！！！
已经有3人回复
-
申博/考博
已经有8人回复
-
295分求调剂
已经有6人回复
-
085600材料与化工调剂
已经有6人回复
-
有没有接收比较快的sci期刊呀，最好在一个月之内的，研三孩子求毕业
已经有7人回复
ky888
银虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 194.6
- 散金: 6
- 帖子: 398
- 在线: 45.5小时
- 虫号: 649359
- 注册: 2008-11-08
- 性别: GG
- 专业: 有机合成
3楼2011-07-02 11:39:52
ky888
银虫 (正式写手)
- 应助: 0 (幼儿园)
- 金币: 194.6
- 散金: 6
- 帖子: 398
- 在线: 45.5小时
- 虫号: 649359
- 注册: 2008-11-08
- 性别: GG
- 专业: 有机合成
2楼2011-07-02 10:17:49
hanklu
金虫 (正式写手)
- 翻译EPI: 3
- 应助: 0 (幼儿园)
- 金币: 1363.2
- 帖子: 502
- 在线: 33.7小时
- 虫号: 244288
- 注册: 2006-04-16
- 专业: 中药制剂
4楼2011-07-04 00:08:47
5