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xzf_23

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[ÇóÖú] °ïæ·­ÒëһƪÓлú»¯Ñ§ÎÄÏ×µÄÌâÄ¿¸úÕªÒª Ҫ׼ȷµã лл

ÌâÄ¿ A Short Total Synthesis of (¡À)-Epimeloscine and (¡À)-Meloscine Enabled by a Cascade Radical Annulation of a Divinylcyclopropane
ÕªÒª ABSTRACT: The first stereoselective synthesis of epime-
loscine has been accomplished in 13 total steps with a longest
linear sequence of 10 steps. The core of the synthesis takes only
five steps, the key ones being acylation, stereoselective tandem
radical cyclization of a divinylcyclopropane to make two rings,
and group-selective ring-closing metathesis of the resulting
divinylcyclopentane to make the last ring.

[ Last edited by xzf_23 on 2011-6-24 at 19:47 ]

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sltmac(½ð±Ò+2): ¸ÐлӦÖú~~ 2011-06-25 11:26:31
xzf_23(½ð±Ò+30, ·­ÒëEPI+1): ¸Ðл 2011-06-26 12:06:43
ÌâÄ¿ A Short Total Synthesis of (¡À)-Epimeloscine and (¡À)-Meloscine Enabled by a Cascade Radical Annulation of a DivinylcyclopropaneÒ»ÖÖ¼ò¶ÌµÄͨ¹ýDivinylcyclopropane´®Áª×ÔÓÉ»ù»·»¯ÊµÏÖµÄ(¡À)-Epimeloscine ºÍ (¡À)-MeloscineÈ«ºÏ³É·½·¨
ÕªÒª ABSTRACT: The first stereoselective synthesis of epimeloscine has been accomplished in 13 total steps with a longest linear sequence of 10 steps.Ê×ÏÈ£¬epimeloscineµÄÁ¢ÌåÑ¡ÔñÐԺϳÉͨ¹ý×ܼÆ13²½°üÀ¨Ò»¸ö×µÄÏßÐÔ´ÎÐò10²½·´Ó¦ÊµÏÖ¡£ The core of the synthesis takes only five steps, the key ones being acylation, stereoselective tandem radical cyclization of a divinylcyclopropane to make two rings, and group-selective ring-closing metathesis of the resulting divinylcyclopentane to make the last ring.ºÏ³ÉµÄºËÐÄ·´Ó¦Ö»ÐèÒª5²½£¬¹Ø¼ü²½Öè°üÀ¨õ£»¯¡¢divinylcyclopropaneµÄÁ¢ÌåÑ¡ÔñÐÔ´®Áª×ÔÓÉ»ù»·»¯ÐγÉÁ½¸ö»·ºÍËùµÃdivinylcyclopentaneµÄ¹ÙÄÜÍÅÑ¡ÔñÐԺϻ·Æç»¯ÐγÉ×îºóµÄ»·¡£

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