| ²é¿´: 1012 | »Ø¸´: 1 | ||
| ±¾Ìû²úÉú 1 ¸ö ·ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴 | ||
xzf_23½ð³æ (СÓÐÃûÆø)
|
[ÇóÖú]
°ïæ·ÒëһƪÓлú»¯Ñ§ÎÄÏ×µÄÌâÄ¿¸úÕªÒª Ҫ׼ȷµã лл
|
|
|
ÌâÄ¿ A Short Total Synthesis of (¡À)-Epimeloscine and (¡À)-Meloscine Enabled by a Cascade Radical Annulation of a Divinylcyclopropane ÕªÒª ABSTRACT: The first stereoselective synthesis of epime- loscine has been accomplished in 13 total steps with a longest linear sequence of 10 steps. The core of the synthesis takes only five steps, the key ones being acylation, stereoselective tandem radical cyclization of a divinylcyclopropane to make two rings, and group-selective ring-closing metathesis of the resulting divinylcyclopentane to make the last ring. [ Last edited by xzf_23 on 2011-6-24 at 19:47 ] |
» ²ÂÄãϲ»¶
Ò»Ö¾Ô¸ÖØÇì´óѧ085700×ÊÔ´Óë»·¾³×Ü·Ö308Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
268Çóµ÷¼Á
ÒѾÓÐ7È˻ظ´
302Çóµ÷¼Á
ÒѾÓÐ11È˻ظ´
306Çóµ÷¼Á
ÒѾÓÐ4È˻ظ´
²ÄÁÏѧѧ˶080502 337Çóµ÷¼Á-Ò»Ö¾Ô¸»ªÖпƼ¼´óѧ
ÒѾÓÐ4È˻ظ´
Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
313Çóµ÷¼Á
ÒѾÓÐ3È˻ظ´
Äϲý´óѧ²ÄÁÏר˶311·ÖÇóµ÷¼Á
ÒѾÓÐ6È˻ظ´
316Çóµ÷¼Á
ÒѾÓÐ6È˻ظ´
346Çóµ÷¼Á[0856]
ÒѾÓÐ7È˻ظ´
8814402
ÖÁ×ðľ³æ (Ö°Òµ×÷¼Ò)
- ·ÒëEPI: 509
- Ó¦Öú: 18 (СѧÉú)
- ¹ó±ö: 0.381
- ½ð±Ò: 12916.1
- É¢½ð: 47
- ºì»¨: 16
- Ìû×Ó: 4183
- ÔÚÏß: 357.8Сʱ
- ³æºÅ: 1184404
- ×¢²á: 2011-01-06
- רҵ: Ò©ÎïѧÆäËû¿ÆÑ§ÎÊÌâ
¡¾´ð°¸¡¿Ó¦Öú»ØÌû
¡ï ¡ï
sltmac(½ð±Ò+2): ¸ÐлӦÖú~~ 2011-06-25 11:26:31
xzf_23(½ð±Ò+30, ·ÒëEPI+1): ¸Ðл 2011-06-26 12:06:43
sltmac(½ð±Ò+2): ¸ÐлӦÖú~~ 2011-06-25 11:26:31
xzf_23(½ð±Ò+30, ·ÒëEPI+1): ¸Ðл 2011-06-26 12:06:43
|
ÌâÄ¿ A Short Total Synthesis of (¡À)-Epimeloscine and (¡À)-Meloscine Enabled by a Cascade Radical Annulation of a DivinylcyclopropaneÒ»ÖÖ¼ò¶ÌµÄͨ¹ýDivinylcyclopropane´®Áª×ÔÓÉ»ù»·»¯ÊµÏÖµÄ(¡À)-Epimeloscine ºÍ (¡À)-MeloscineÈ«ºÏ³É·½·¨ ÕªÒª ABSTRACT: The first stereoselective synthesis of epimeloscine has been accomplished in 13 total steps with a longest linear sequence of 10 steps.Ê×ÏÈ£¬epimeloscineµÄÁ¢ÌåÑ¡ÔñÐԺϳÉͨ¹ý×ܼÆ13²½°üÀ¨Ò»¸ö×µÄÏßÐÔ´ÎÐò10²½·´Ó¦ÊµÏÖ¡£ The core of the synthesis takes only five steps, the key ones being acylation, stereoselective tandem radical cyclization of a divinylcyclopropane to make two rings, and group-selective ring-closing metathesis of the resulting divinylcyclopentane to make the last ring.ºÏ³ÉµÄºËÐÄ·´Ó¦Ö»ÐèÒª5²½£¬¹Ø¼ü²½Öè°üÀ¨õ£»¯¡¢divinylcyclopropaneµÄÁ¢ÌåÑ¡ÔñÐÔ´®Áª×ÔÓÉ»ù»·»¯ÐγÉÁ½¸ö»·ºÍËùµÃdivinylcyclopentaneµÄ¹ÙÄÜÍÅÑ¡ÔñÐԺϻ·Æç»¯ÐγÉ×îºóµÄ»·¡£ »¯ºÏÎïÃû³ÆÂ¥Ö÷Ó¦¸Ã±È±ðÈËÇå³þ£¬ÎÒ²éËÆÎÞ±ØÒª£¬ÇëÂ¥Ö÷Ìæ»» |
2Â¥2011-06-25 09:26:58













»Ø¸´´ËÂ¥