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±¾Ìû²úÉú 1 ¸ö ·­ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴

ÓÚÌï9858

ľ³æ (СÓÐÃûÆø)

[ÇóÖú] ·­Òë2¾ä»°

The present work focuses on quantifying the dispersion and
separation resolution of a continuous hydrodynamic particle
separation technique. We have developed a compact analytical
expression for particle dispersion and separation resolution that
accounts for Brownian motion and wall roughness. We measure
the dispersion and separation resolution as a function of the device
pinched width dimensions (15-30 ¨ªm), device aspect ratio (20-
30 approximately), and particle diameter difference (2-15 ¨ªm).
We show that the device wall roughness plays a key role in the
dispersion and separation resolution. Mylar masks result in rough
side walls and compromised device performance. We observe that
particles appear closer to the sidewall than predicted by linear
theory which results in lower separation resolution. In this study,
dispersion due to wall roughness is a limiting factor for obtaining
high-resolution separations. Our results suggest that particles
whose diameters are of the order of the wall roughness cannot
be separated using PFF. The results show separation resolutions
greater than unity can be obtained for devices having aspect ratios
larger than 20 and particle size differences greater than 10 ¨ªm. A
better theoretical model for dispersion due to wall roughness is
needed that incorporates the effect of advection of particles near
the wall that may depend on the Peclet number in this region.
Future work may also include high fidelity computational modeling
that will predict why particles move closer to the wall than
predicted by linear theory.

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