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于田9858木虫 (小有名气)
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The present work focuses on quantifying the dispersion and separation resolution of a continuous hydrodynamic particle separation technique. We have developed a compact analytical expression for particle dispersion and separation resolution that accounts for Brownian motion and wall roughness. We measure the dispersion and separation resolution as a function of the device pinched width dimensions (15-30 ím), device aspect ratio (20- 30 approximately), and particle diameter difference (2-15 ím). We show that the device wall roughness plays a key role in the dispersion and separation resolution. Mylar masks result in rough side walls and compromised device performance. We observe that particles appear closer to the sidewall than predicted by linear theory which results in lower separation resolution. In this study, dispersion due to wall roughness is a limiting factor for obtaining high-resolution separations. Our results suggest that particles whose diameters are of the order of the wall roughness cannot be separated using PFF. The results show separation resolutions greater than unity can be obtained for devices having aspect ratios larger than 20 and particle size differences greater than 10 ím. A better theoretical model for dispersion due to wall roughness is needed that incorporates the effect of advection of particles near the wall that may depend on the Peclet number in this region. Future work may also include high fidelity computational modeling that will predict why particles move closer to the wall than predicted by linear theory. |
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