| 查看: 1281 | 回复: 3 | |||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||
putin092910木虫 (著名写手)
|
[求助]
帮看看chemcomm 索要版权时提的一句话，是什么意思呢？
|
||
|
According to our Guidelines for Authors at http://www.rsc.org/Publishing/Re ... icy/Journals/CC.asp we require a brief statement justifying why your article should be published in ChemComm. When preparing your letter please bear in mind the following criteria:Communications should be a concise preliminary account of original and significant research. Communications should appeal to either the wide general readership or be of exceptional interest to the specialist. I would be grateful if you would email your letter to chemcomm@rsc.org as soon as possible. Please remember to quote your manuscript reference number in all correspondence. 这是什么意思呢，是要我写封信给编辑介绍亮点吗？ |
回复此楼» 猜你喜欢
288求调剂，一志愿华南理工大学071005
已经有5人回复
-
一志愿中国海洋大学，生物学，301分，求调剂
已经有5人回复
-
294求调剂材料与化工专硕
已经有12人回复
-
0856调剂，是学校就去
已经有5人回复
-
0817 化学工程 299分求调剂 有科研经历 有二区文章
已经有13人回复
-
梁成伟老师课题组欢迎你的加入
已经有11人回复
-
复试调剂
已经有6人回复
-
0703化学调剂 ，六级已过，有科研经历
已经有11人回复
-
321求调剂
已经有10人回复
-
东华理工大学化材专业26届硕士博士申请
已经有8人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 请问Returned the first comment of reviewers这是什么意思？
已经有3人回复
- 重金求助 谁能帮我翻译客户的一句话 是什么意思啊 在线等各位达人
已经有5人回复
- 帮忙看看这个审稿意见是什么意思
已经有4人回复
- 帮我看看这个导师是什么意思呢。。
已经有5人回复
- 意见返回，麻烦大家帮忙看看这是什么意思，还有希望吗
已经有9人回复
- 大家帮看看这个状态时什么意思啊？
已经有5人回复
- 关于ChemComm的编辑这样的回信是何意思？
已经有26人回复
- 分析化学与药物分析领域都有哪些著名期刊杂志？？？
已经有8人回复
- 【求助】麻烦大家帮忙看一下德国学校的申请表上这一句话是什么意思呢？
已经有18人回复
- Talanta文章被拒，但请各位帮我看看这样的审稿意见是什么意思
已经有15人回复
- 大家帮我看看这个拒稿信是什么意思？
已经有10人回复
- 大家帮忙看看编辑这句话是什么意思啊，谢谢
已经有12人回复
croninszl
铁杆木虫 (职业作家)
★★★★★★★★★★★
- SEPI: 1
- 应助: 22 (小学生)
- 贵宾: 0.001
- 金币: 6191.8
- 散金: 7530
- 红花: 27
- 帖子: 4446
- 在线: 543.2小时
- 虫号: 131510
- 注册: 2005-12-12
- 性别: GG
- 专业: 有机合成
【答案】应助回帖
putin092910(金币+3): 2011-06-04 13:07:04
|
给你个参考吧！ Significance of the work Biginelli reaction is an important organic transformation for the synthesis of dihydropyrimidinones compounds which exhibit a wide range of biological activities such as antiviral, antitumor, antibacterial and antiflammatory properties. The one-pot reaction usually proceeds well in the presence of Lewis acids or protic acids. Just as Biginelli reaction which operates in the presence of Lewis acid or protic acid, those multi-component reactions for the preparation of new dihydropyrimidinones using various active methylene compounds instead of acetoacetate derivatives, such as such as 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, 1-tetralone, acetophenone, cyclopentanone, aliphatic aldehydes and-oxodithioesters are also carried out using Lewis acid or protic acid such as HCl, TMSCl/NaI, FeCl3 and YbCl3. However, till now, there is no report on the development of one-pot Biginelli-type reaction under basic conditions. In addition, there are few studies on the mechanism of Biginelli reaction. We envisioned that if the Biginelli-type reaction can be developed to carry out under basic conditions using Brönsted bases rather than Lewis acids it will provide an attractive alternative to existing methodologies and help deepen our understanding of Biginelli reaction. In this report, we describe a novel Brönsted base-promoted one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-one via a three-component condensation of aldehyde, 2-phenylacetophenone, and urea or thiourea. The reactions proceeded efficiently in the presence of a catalytic amount of Brönsted bases (20 mol% t-BuOK) to afford dihydropyrimidinone compounds in moderate to good yields. The method is simple, convenient, efficient, and expects to be a useful synthetic protocol for the synthesis of a wide range of novel drug-like dihydropyrimidinone compounds. In addition, a detailed mechanistic study was carried out. It was interesting to observe that the reactions with the use of thiourea as substrate proceeds via intermediate enone 5; whereas, the use of urea as substrate occurred via bis-urea compound 8. We forecast that the use of bisurea 8 as substrate for the synthesis of 3,4-dihydropyrimidin-2(1H)-one will gain popularity in future. To the best of our knowledge, this is the first Brönsted base-promoted one-pot approach for the synthesis of Biginelli-like scaffold compounds of dihydropyrimidinones. In addition, it was the first observation that the Biginelli-type reaction using urea or thiourea proceeds through two different pathways. Compared with commonly employed methods for the preparation of dihydropyrimidinones using Lewis acid or protic acid, the methodology presented herein provided a novel, convenient, efficient and cheap access to new dihydropyrimidinones in a one-pot manner. As such, this paper deserves to be published as a Communication in chemical communications, in view of potent synthetic value associated with this method and its potential to draw the attention of many readers of chemical communications. |
4楼2011-06-03 17:47:35
croninszl
铁杆木虫 (职业作家)
★★★★★★★★★★★
- SEPI: 1
- 应助: 22 (小学生)
- 贵宾: 0.001
- 金币: 6191.8
- 散金: 7530
- 红花: 27
- 帖子: 4446
- 在线: 543.2小时
- 虫号: 131510
- 注册: 2005-12-12
- 性别: GG
- 专业: 有机合成
2楼2011-06-03 17:38:49
lxying
至尊木虫 (著名写手)
- 应助: 146 (高中生)
- 金币: 12568.1
- 红花: 15
- 帖子: 1395
- 在线: 273.4小时
- 虫号: 551837
- 注册: 2008-04-28
- 性别: GG
- 专业: 理论和计算化学
3楼2011-06-03 17:40:36
