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小木虫论坛-学术科研互动平台 » 学术交流区 » 论文投稿 » 投稿求助 » 帮看看chemcomm 索要版权时提的一句话，是什么意思呢？
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putin092910

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[求助] 帮看看chemcomm 索要版权时提的一句话，是什么意思呢？

According to our Guidelines for Authors at http://www.rsc.org/Publishing/Re ... icy/Journals/CC.asp we require a brief statement justifying why your article should be published in ChemComm. When preparing your letter please bear in mind the following criteria:Communications should be a concise preliminary account of original and significant research. Communications should appeal to either the wide general readership or be of exceptional interest to the specialist.

I would be grateful if you would email your letter to chemcomm@rsc.org as soon as possible. Please remember to quote your manuscript reference number in all correspondence.

这是什么意思呢，是要我写封信给编辑介绍亮点吗？
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1楼2011-06-03 17:18:46
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croninszl

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putin092910(金币+3): 2011-06-04 13:06:39
每次投稿都需要在给编辑的信中（cover letter）写上你工作的重要性，亮点。

也就是：significance of the work!
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2楼2011-06-03 17:38:49
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lxying

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putin092910(金币+3): 2011-06-04 13:06:47
介绍文章的创新点、价值等突出亮点的内容。就是让你自己夸一下自己的东西，给editor看，接受之后估计也给读者看，引人眼球！
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明天会更好！
3楼2011-06-03 17:40:36
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croninszl

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putin092910(金币+3): 2011-06-04 13:07:04
给你个参考吧！

Significance of the work

Biginelli reaction is an important organic transformation for the synthesis of dihydropyrimidinones compounds which exhibit a wide range of biological activities such as antiviral, antitumor, antibacterial and antiflammatory properties. The one-pot reaction usually proceeds well in the presence of Lewis acids or protic acids.

Just as Biginelli reaction which operates in the presence of Lewis acid or protic acid, those multi-component reactions for the preparation of new dihydropyrimidinones using various active methylene compounds instead of acetoacetate derivatives, such as such as 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, 1-tetralone, acetophenone, cyclopentanone, aliphatic aldehydes and-oxodithioesters are also carried out using Lewis acid or protic acid such as HCl, TMSCl/NaI, FeCl3 and YbCl3.

However, till now, there is no report on the development of one-pot Biginelli-type reaction under basic conditions. In addition, there are few studies on the mechanism of Biginelli reaction. We envisioned that if the Biginelli-type reaction can be developed to carry out under basic conditions using Brönsted bases rather than Lewis acids it will provide an attractive alternative to existing methodologies and help deepen our understanding of Biginelli reaction. In this report, we describe a novel Brönsted base-promoted one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-one via a three-component condensation of aldehyde, 2-phenylacetophenone, and urea or thiourea. The reactions proceeded efficiently in the presence of a catalytic amount of Brönsted bases (20 mol% t-BuOK) to afford dihydropyrimidinone compounds in moderate to good yields. The method is simple, convenient, efficient, and expects to be a useful synthetic protocol for the synthesis of a wide range of novel drug-like dihydropyrimidinone compounds. In addition, a detailed mechanistic study was carried out. It was interesting to observe that the reactions with the use of thiourea as substrate proceeds via intermediate enone 5; whereas, the use of urea as substrate occurred via bis-urea compound 8. We forecast that the use of bisurea 8 as substrate for the synthesis of 3,4-dihydropyrimidin-2(1H)-one will gain popularity in future.
To the best of our knowledge, this is the first Brönsted base-promoted one-pot approach for the synthesis of Biginelli-like scaffold compounds of dihydropyrimidinones. In addition, it was the first observation that the Biginelli-type reaction using urea or thiourea proceeds through two different pathways. Compared with commonly employed methods for the preparation of dihydropyrimidinones using Lewis acid or protic acid, the methodology presented herein provided a novel, convenient, efficient and cheap access to new dihydropyrimidinones in a one-pot manner. As such, this paper deserves to be published as a Communication in  chemical communications, in view of potent synthetic value associated with this method and its potential to draw the attention of many readers of chemical communications.
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4楼2011-06-03 17:47:35
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