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[求助]
医药化学方面 自己已经翻译了一半，还有几句话还得请教您，专业性有点强。
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加粗部分的翻译需要请您帮忙翻译成英文，并且希望您帮我看下我的翻译是否恰当！谢谢 吲哚美辛是一类抗炎活性较强的非甾体抗炎药，但由于它对胃肠道的刺激性较大，且对肝功能、造血系统以及中枢神经系统都有较大的副作用，因此需对它进行结构改造，得到副作用相对较低的吲哚类药物。探讨其构效关系。方法：根据已上市的吲哚美辛的构效关系以及分子模拟研究的结果，设计了2-甲基-1-(1,3-二甲基-3-溴-1H-吡唑-5-甲酰基)-5-甲氧基-1H-吲哚-3-乙酸。以1,3-二甲基-3-溴-1H-吡唑-5-甲酸为原料，经多步反应合成目标化合物。结果与结论：合成了未见文献报道的新化合物，所有目标化合物的结构经IR 1H-NMR、MS谱和元素分析确证。 study the structure-activity relationships(SAR)of the title compounds．. Methods: Based on the SAR of Indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized . With 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid as a raw material, a multi-step reaction to synthetic the target compound. Results and conclusion: did not see literature synthesized reported the new compounds, The structures of target compounds were confirmed by IR，1H—NMR，MS spectra and elemental analysis. 吲哚美辛 Indomethacin 对氯苯甲酸 4-Chlorobenzoic acid 1,3-二甲基-4-溴-1H-吡唑-5-甲酸 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid 对甲氧基苯胺 p-Anisidine 亚硫酸钠 Sodium sulfite 锌粉 Zinc dust 对甲氧基苯肼磺酸钠 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE 二氯亚砜 Thionyl chloride 1,3-二甲基-4-溴-1H-吡唑-5-甲酰氯 4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl chloride 乙酰丙酸 Levulinic acid 2-甲基-1-(1,3-二甲基-4-溴-1H-吡唑-5-甲酰基)-5-甲氧基-1H-吲哚-3-乙酸 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid [ Last edited by hupine on 2011-5-29 at 00:46 ] |
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这个求助帖冷场了 
2楼2011-05-29 19:54:59
zxs1989
金虫 (著名写手)
Dance with Google
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3楼2011-05-30 01:20:30
zxs1989
金虫 (著名写手)
Dance with Google
- 翻译EPI: 27
- 应助: 12 (小学生)
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【答案】应助回帖
★ ★
hupine(金币+13, 翻译EPI+1): 非常感谢 2011-05-30 08:28:45
Mally89(金币+2): 感谢应助！~欢迎常来！~ 2011-05-30 11:18:23
hupine(金币+13, 翻译EPI+1): 非常感谢 2011-05-30 08:28:45
Mally89(金币+2): 感谢应助！~欢迎常来！~ 2011-05-30 11:18:23
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Indomethacin, although a potent non-steroid antiinflammatory drug, has been known as a strong gastrointestine irritant and for its serious side effects on the liver function, the hemopoietic system, and the central nervous system. It’s highly desirable to obtain indole drugs with relatively small adverse effects via structural reformation of indomethacin and to study their structure-activity relationships(SAR)． Methods: Based on the SAR of indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized through a multi-step reaction from 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid. Results and conclusion: New indole compounds which have not been reported before were synthesized, and all their structures were confirmed by IR，1H—NMR，MS, and elemental analysis. 逻辑关系稍有改动。并未严格按照兄台的中文直译 |
4楼2011-05-30 02:32:48