金虫 (著名写手)
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【答案】应助回帖
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hupine(金币+13, 翻译EPI+1): 非常感谢 2011-05-30 08:28:45
Mally89(金币+2): 感谢应助！~欢迎常来！~ 2011-05-30 11:18:23
Indomethacin, although a potent non-steroid antiinflammatory drug, has been known as a strong gastrointestine irritant and for its serious side effects on the liver function, the hemopoietic system, and the central nervous system. It’s highly desirable to obtain indole drugs with relatively small adverse effects via structural reformation of indomethacin and to study their structure-activity relationships(SAR)． Methods: Based on the SAR of indomethacin and related molecular modeling studies, 2-(1-(4-bromo-1,3-dimethyl-1H-pyrazole-5-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid were designed and synthesized through a multi-step reaction from 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid. Results and conclusion: New indole compounds which have not been reported before were synthesized, and all their structures were confirmed by IR，1H—NMR，MS, and elemental analysis.
逻辑关系稍有改动。并未严格按照兄台的中文直译 |
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