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1楼2011-04-26 16:37:41

gubangjin

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只查到 L(+)-酒石酸的bp2009标准

网事已随风而去!

2楼2011-04-26 17:02:04

hardee

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warlen(金币+5): 虽然不是，谢谢了 2011-04-26 17:18:00

是这个吗：
http://g.zhubajie.com/urllink.php?id=110473371vfrue3xa9nx9om5

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3楼2011-04-26 17:04:34

hardee

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上面的是L型的。不是LZ想要的。。。

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4楼2011-04-26 17:08:28

gubangjin

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引用回帖:

Originally posted by hardee at 2011-04-26 17:04:34:
是这个吗：
http://g.zhubajie.com/urllink.php?id=110473371vfrue3xa9nx9om5

这个就是L(+)-酒石酸的标准

网事已随风而去!

5楼2011-04-26 17:08:44

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Tartaric Acid

General Notices

(Ph Eur monograph 0460)

C4H6O6 150.1 87-69-4

Ph Eur

DEFINITION
(2R,3R)-2,3-Dihydroxybutanedioic acid.

Content
99.5 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance
White or almost white, crystalline powder or colourless crystals.

Solubility
Very soluble in water, freely soluble in ethanol (96 per cent).

IDENTIFICATION
A.  Solution S (see Tests) is strongly acid (2.2.4).

B.  It gives the reactions of tartrates (2.3.1).

TESTS
Solution S
Dissolve 5.0 g in distilled water R and dilute to 50 ml with the same solvent.

Appearance of solution
Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y6 (2.2.2, Method II).

Specific optical rotation (2.2.7)
+ 12.0 to + 12.8 (dried substance)

Dissolve 5.00 g in water R and dilute to 25.0 ml with the same solvent.

Oxalic acid
Maximum 350 ppm, calculated as anhydrous oxalic acid.

Dissolve 0.80 g in 4 ml of water R. Add 3 ml of hydrochloric acid R and 1 g of zinc R in granules and boil for 1 min. Allow to stand for 2 min. Collect the liquid in a test-tube containing 0.25 ml of a 10 g/l solution of phenylhydrazine hydrochloride R and heat to boiling. Cool rapidly, transfer to a graduated cylinder and add an equal volume of hydrochloric acid R and 0.25 ml of a 50 g/l solution of potassium ferricyanide R. Shake and allow to stand for 30 min. Any pink colour in the solution is not more intense than that in a standard prepared at the same time in the same manner using 4 ml of a 0.1 g/l solution of oxalic acid R.

Chlorides (2.4.4)
Maximum 100 ppm.

Dilute 5 ml of solution S to 15 ml with water R.

Sulphates (2.4.13)
Maximum 150 ppm.

Dilute 10 ml of solution S to 15 ml with distilled water R.

Calcium (2.4.3)
Maximum 200 ppm.

To 5 ml of solution S add 10 ml of a 50 g/l solution of sodium acetate R in distilled water R.

Heavy metals (2.4.8)
Maximum 10 ppm.

2.0 g complies with test C. Prepare the reference solution using 2 ml of lead standard solution (10 ppm Pb) R.

Loss on drying (2.2.32)
Maximum 0.2 per cent, determined on 1.000 g by drying in an oven at 105 °C

Sulphated ash (2.4.14)
Maximum 0.1 per cent, determined on 1.0 g.

ASSAY
Dissolve 0.650 g in 25 ml of water R. Titrate with 1 M sodium hydroxide using 0.5 ml of phenolphthalein solution R as indicator, until a pink colour is obtained.

1 ml of 1 M sodium hydroxide is equivalent to 75.05 mg of C4H6O6.

Ph Eur

6楼2011-05-07 14:50:03

dannyboy

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★ ★
chinarencxp(金币+2): 谢谢积极参与 2011-05-07 19:58:11

(S )-Lactic Acid

General Notices

(Ph Eur monograph 1771)

C3H6O3 90.1 77-33-4

Ph Eur

DEFINITION
Mixture of (S)-2-hydroxypropanoic acid, its condensation products, such as lactoyl-lactic acid and polylactic acids, and water. The equilibrium between lactic acid and polylactic acids depends on the concentration and temperature.

Content
88.0 per cent m/m to 92.0 per cent m/m of C3H6O3, not less than 95.0 per cent of which is the (S)-enantiomer.

CHARACTERS
Appearance
Colourless or slightly yellow, syrupy liquid.

Solubility
Miscible with water and with ethanol (96 per cent).

IDENTIFICATION
A.  Dissolve 1 g in 10 ml of water R. The solution is strongly acidic (2.2.4).

B.  Relative density (2.2.5): 1.20 to 1.21.

C.  It gives the reaction of lactates (2.3.1).

D.  It complies with the limits of the assay.

TESTS
Solution S
Dissolve 5.0 g in 42 ml of 1 M sodium hydroxide and dilute to 50 ml with distilled water R.

Appearance
The substance to be examined is not more intensely coloured than reference solution Y6 (2.2.2, Method II).

Ether-insoluble substances
Dissolve 1.0 g in 25 ml of ether R. The solution is not more opalescent than the solvent used for the test.

Sugars and other reducing substances
To 1 ml of solution S add 1 ml of 1 M hydrochloric acid, heat to boiling, allow to cool and add 1.5 ml of 1 M sodium hydroxide and 2 ml of cupri-tartaric solution R. Heat to boiling. No red or greenish precipitate is formed.

Methanol (2.4.24)
Maximum 50 ppm, if intended for use in the manufacture of parenteral dosage forms.

Citric, oxalic and phosphoric acids
To 5 ml of solution S add dilute ammonia R1 until slightly alkaline (2.2.4). Add 1 ml of calcium chloride solution R. Heat on a water-bath for 5 min. Both before and after heating, any opalescence in the solution is not more intense than that in a mixture of 1 ml of water R and 5 ml of solution S.

Sulphates (2.4.13)
Maximum 200 ppm.

Dilute 7.5 ml of solution S to 15 ml with distilled water R.

Calcium (2.4.3)
Maximum 200 ppm.

Dilute 5 ml of solution S to 15 ml with distilled water R.

Heavy metals (2.4.8)
Maximum 10 ppm.

12 ml of solution S complies with limit test A. Prepare the reference solution using lead standard solution (1 ppm Pb) R.

Sulphated ash (2.4.14)
Maximum 0.1 per cent, determined on 1.0 g.

Bacterial endotoxins (2.6.14)
Less than 5 IU/g if intended for use in the manufacture of parenteral dosage forms without a further appropriate procedure for the removal of bacterial endotoxins. Before use, neutralise the test solution to pH 7.0-7.5 with strong sodium hydroxide solution R and shake vigorously.

ASSAY
Place 1.000 g in a ground-glass-stoppered flask and add 10 ml of water R and 20.0 ml of 1 M sodium hydroxide. Close the flask and allow to stand for 30 min. Using 0.5 ml of phenolphthalein solution R as indicator, titrate with 1 M hydrochloric acid until the pink colour is discharged.

1 ml of 1 M sodium hydroxide is equivalent to 90.1 mg of C3H6O3.

(S)-enantiomer
Transfer an amount of the substance to be examined equivalent to 2.00 g of lactic acid into a round-bottomed flask, add 25 ml of 1 M sodium hydroxide and boil gently for 15 min. Cool down and adjust to pH 7.0 using 1 M hydrochloric acid. Add 5.0 g of ammonium molybdate R, dissolve and dilute to 50.0 ml with water R. Filter and measure the angle of optical rotation (2.2.7). Calculate the percentage content of (S)-enantiomer using the expression:

α
=
angle of optical rotation (absolute value),

m
=
mass of the substance to be examined, in grams,

c
=
percentage content of C3H6O3 in the substance to be examined.

The complex of (S)-lactic acid formed under these test conditions is laevorotatory.

LABELLING
The label states, where applicable, that the substance is suitable for use in the manufacture of parenteral dosage forms.

Ph Eur

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7楼2011-05-07 14:50:59